Drs. Chiocca and Breakefield bring together in Gene Therapy for Neurological Disorders and Brain Tumors many of the leading gene therapy researchers and clinicians to capture the breadth of the field-from basic vector technology to current and future clinical applications. The authoritative contributions provide cutting-edge reviews of the vectors available for gene transfer to the central nervous system, the strategies against CNS tumors, the potential strategies against neurologic disorders, and the limitations of today's gene therapy approaches. Also discussed are significant applications of gene therapy to brain tumors, Parkinson's disease, ischemia, and Huntington's chorea.

Gene Therapy for Neurological Disorders and Brain Tumors illuminates the rapidly developing applications of gene transfer technologies to the treatment of a wide range of neurological disorders and brain tumors. Readers will learn the current delivery methods for transgenes, will learn the characteristics of the transgene delivery vectors, and come to more fully understand gene therapies for both neuro-oncologic and neurologic disorders.

Klappentext

Leading gene therapy researchers and clinicians illuminate the field-from basic vector technology to current and future clinical applications in neurology. The authoritative contributors provide cutting-edge reviews of the vectors available for gene transfer to the central nervous system, the strategies against CNS tumors, the potential strategies against neurologic disorder, and the limitations of today's gene therapy approaches. Also discussed are significant applications of gene therapy to brain tumors, Parkinson's disease, ischemia, and Huntington's chorea. Readers will learn the current delivery methods for transgenes, will learn the characteristics of transgene delivery vectors, and come to understand the therapy for both neuro-oncologic and neurologic disorders.

Inhalt

Part i: Vectors and Promoters. Introduction, J. Glorioso. Retrovirus Vectors and Regulatable Promoters, S. Reeves. Adenovirus Vectors, M. Cotten. Herpes Simplex Virus: Recombinant Vectors, P. A. Johnson. Herpes Simplex Virus: Amplicon Vectors, C. Fraefel, X. O. Breakefield, and D. Jacoby. Adeno-Associated Virus Vectors, F. I. Smith and T. J. McCown. Epstein-Barr Virus Vectors, J.-M. H. Vos, K. B. Quattrocchi, and B. J. Wendelburg. Lentiviral Vectors, D. Trono, U. Blømer, and L. Naldini. Promoters for Expression of Gene Products Within Neurons and Glia, J. W. Henson. Immunological Issues, J. G. Smith and S. L. Eck. Part ii: Neuro-oncology. Current Treatment Modalities for Brain Tumor, S. B. Tatter and G. R. Harsh IV. Experimental and Clinical Gene Therapies for Brain Tumors, E. A. Chiocca. Tumor Suppressor Gene Therapy for Brain Tumors, C. Gomez-Manzano, J. Fueyo, A. P. Kyritsis, W.K. A. Yung. Cytokine-Based Gene Therapy for Brain Tumors, J. H. Sampson, D. D. Bigner, and G. Dranoff. Delivery of Therapeutic Genes to Brain and Intracerebral Tumors, L. L. Muldoon, R. A. Kroll, M. A. Pagel, S. Roman-Goldstein, and E. A. Neuwelt. Rat Brain Tumor Models and Statistical Evaluation of Survival Data in Experimental Neuro-Oncology, R. F. Barth and M. L. Moeschberger. Part iii: Neurological Disorders. Neurological Disorders: An Overview, A. B. Young. Gene Transfer for Adult CNS Regeneration and Aging, M.C. Senut, I. Aubert, P.J. Horner, and F. H. Gage. Gene Therapy for Parkinson's Disease, M. C. Bohn and D. L. Choi-Lundberg. Gene Therapy for Ischemic Stroke, P. A. Pechan, M. Fujii, C. Fraefel, Andreas Jacobs, and M. A. Moskowitz. Gene Therapy for the Lysomal Storage Diseases, E. M. Kaye. Gene Therapy for Pain, G. Davar. Gene Therapy of Huntington's Disease, O. Isaesen and N. Haque. Index.