There has been an explosion of research related to free radicals and antioxidants in recent years, and hundreds of laboratories worldwide are actively involved in many as­ pects of free radicals, oxidative stress, and antioxidants. The literature on these topics in­ creases exponentially every year. Over the last few years, we have been fortunate to witness a widespread recognition of the important role of free radicals in a wide variety of pathological conditions including diseases such as atherosclerosis, cardiovascular and neurological diseases, ischemia, emphysema, diabetes, radiation injury, cancer, etc. In ad­ dition, many laboratories are studying the role of free radicals in the inexorable process of aging. Increased evidence involves free radicals with the etiology of various diseases, thereby suggesting the use of antioxidants as a viable therapeutic approach for the treat­ ment of free radical mediated pathologies. Despite these impressive developments, many important aspects of free radical and antioxidant research are open for investigation. It is important to understand the overall mechanisms involved in free radical mediated physiological and pathological conditions. This knowledge will undoubtedly lead to the development of new therapeutic approaches to prevent or control free radical related diseases. This book contains the proceedings of the NATO Advanced Study Institute (ASI) on "Free Radicals, Oxidative Stress, and Antioxidants: Pathological and Physiological Sig­ nificance," which was held in Antalya, Turkey from May 24-June 4, 1997.

Inhalt

Mechanisms Involved in Free Radical Reactions ; Iron in Free Radical Reactions and Antioxidant Protection; J.M.C. Gutteridge. Non-Chelation Dependent Redox Actions of Desferrioxamine; B.Z. Zhu, et al. The Effects of Oxidative Stress on the Redox System of the Human Erythrocyte; I.H. Ögüs, et al. Free Radicals in Health and Disease: Reactive Oxygen Species (ROS) and Alteration of F0F1-ATP Synthase in Aging and Liver Regeneration; F. Guerrieri, et al. Free Radicals and Antioxidants in Physical Exercise; J. Vina, et al. The Role of Free Radical Mediation of Protein Oxidation in Aging and Disease; E.R. Stadtman. Antioxidants: Mechanisms of Antioxidant Action; E. Cadenas. Repair Systems and Inducible Defenses Against Oxidant Stress; K.J.A. Davies. The `Push-Pull Mechanism': Protection Against Site-Specific and Transition Metal-Mediated Damage; M. Chevion, et al. Methodology: EPR Spectroscopy of Phenolic Plant Antioxidants; W. Bors, et al. Clastogenic Factors as Biomarkers of Oxidative Stress. Their Usefulness for Evaluation of the Efficacy of Antioxidant Treatments; I. Emeritt. Chemiluminescence Measurements for the Detection of Free Radical Species; A.S. Yalç, et al. 21 Additional Articles. Index.