This book presents the proceedings of the 19th International Conference of the Indian Society of Ergonomics (ISE) titled 'Humanizing Work and Work Environment (HWWE-2021)', held at the Center for Ergonomics: User-centered Design and Occupational Wellbeing, Department of Design, Indian Institute of Technology (IIT) Guwahati, Assam, India on December 1-3, 2021. By highlighting the latest theories and models, as well as cutting-edge technologies and applications, and by combining findings from a range of disciplines, including engineering, design, healthcare, management, computer science, and behavioral science, it provides researchers and practitioners alike with a comprehensive, timely guide on user-centered design for quality life, human factors and ergonomics, design applications, cognitive processing, and response. It also offers an excellent source of innovative ideas to stimulate future discussions and developments aimed at applying knowledge and techniques to optimize system performance while at the same time promoting the health, safety, and wellbeing of individuals. The proceedings include papers from researchers and practitioners, scientists and physicians, institutional leaders, managers, and policymakers that contribute to constructing the Human Factors and Ergonomics approach across a variety of methodologies, domains, and productive sectors.