In Endocrinology of Breast Cancer, Andrea Manni, MD, organizes a cutting-edge review of how derangements in the hormonal and growth factor mechanisms controlling normal mammary development lead to breast cancer. Drawing on the multidisciplinary expertise of leading authorities, the book highlights the roles of oncogenes and tumor suppressor genes, spelling out the importance of autocrine/paracrine loops (e.g., stromal epithelial interactions) in supporting breast cancer cell proliferation and the progression to hormone independence. The book's many prominent contributors also illuminate significant recent advances in the biochemistry and physiology of hormone receptors and review the state-of -the-art in the endocrine therapy of breast cancer.
Providing a unique, integrated overview of the most significant developments involving the hormonal aspects of breast cancer, Endocrinology of Breast Cancer constitutes an invaluable, broad-ranging resource for all basic scientists, clinicians, and fellows-in-training who want to better understand and treat this most common malignancy.

Klappentext

A cutting-edge review of how derangements in the hormonal and growth factor mechanisms controlling normal mammary development lead to breast cancer. Drawing on the multidisciplinary expertise of leading authorities, the book highlights the roles of oncogenes and tumor suppressor genes, spelling out the importance of autocrine/paracrine loops (e.g., stromal epithelial interactions) in supporting breast cancer cell proliferation and the progression to hormone independence. The book's many prominent contributors also illuminate significant recent advances in the biochemistry and physiology of hormone receptors and review the state-of -the-art in the endocrine therapy of breast cancer. Endocrinology of Breast Cancer provides a unique integrated overview of the most significant basic and clinical developments concerning the hormonal aspects of breast cancer.

Inhalt

Part I. Hormonal Control of Mammary Development and Growth. Hormonal Control of Normal Breast Morphology and Function, Richard E. Blackwell and Karen R. Hammond. Interactions Between Estradiol and Progesterone in Normal Breast: Implications for Mammary Carcinogenesis, Geneviève Plu-Bureau, Philippe Touraine, and Pierre Mauvais-Jarvis. Expression and Regulation of Insulin-like Growth Factors and Their Binding Proteins in the Normal Breast, Monica M. Richert and Teresa L. Wood. Part II. Carcinogenesis. Estrogens and Breast Cancer: An Epidemiologic Perspective, Heather Spencer Feigelson and Brian E. Henderson. Androgens, Estrogens, and Breast Cancer Risk, V. H. T. James. Local Estrogen Production: Is Aromatase an Oncogene, Rajeshwar Rao Tekmal and Richard J. Santen. Oncogenes and Mammary Carcinogenesis, Maria Luisa Veronese, Florencia Bullrich, and Carlo M. Croce. Categorization of Breast Cyst Fluid and Breast Cancer Risk, Luigi Dogliotti and Pasquale Caraci. Part III. Tumor Progression. The Role of Tumor Suppressor Genes in Breast Cancer Progression, Robert Callahan. Oncogene Activation and Breast Cancer Progression, Richard J. Pietras and Mark D. Pegram. Interactions Between Stroma and Epithelium in Breast Cancer: Implications for Tumor Genesis, Growth, and Progression, Kevin J. Cullen, Sahana S. Kaup, and Audrey A. Rasmussen. The Role of Angiogenesis in the Transition to Hormone Independence and Acquisition of the Metastatic Phenotype, Francis G. Kern. Role of the IGF System in Breast Cancer Proliferation and Progression, A. V. Lee and D. Yee. Prognostic and Predictive Factors in Breast Cancer, Jan G. M. Klijn, Els M. J. J. Berns, and John A. Foekens. Role of the Polyamine Pathway in the Natural History of Breast Cancer, Andrea Manni. Aromatase Inhibitors in Breast Carcinoma, Harold A. Harvey. Part IV. Hormone Receptors and Their Functions. Role of Progestins and Progesterone Receptors in Breast Cancer Biology, Anne Guiochon-Mantel and Edwin Milgrom. Prolactin andits Receptors in Human Breast Cancer, Barbara K. Vonderhaar. Part V. Endocrine Therapy of Breast Cancer. Pharmacology and Use of Antiestrogens in Treatment and Chemoprevention of Breast Cancer, William J. Gradishar and V. Craig Jordan. LHRH Superagonists and Antagonists in the Treatment of Breast Cancer, P. N. Mainwaring and M. Dowsett. Part VI. Benign Breast Disease. Benign Breast Lesions: Pathologic Classification and Risk Potential, Roy A. Jensen. Hormonal Treatment of Fibrocystic Disease, Luigi Dogliotti and Pasquale Caraci. Gynecomastia and Galactorrhea, David L. Kleinberg. Index.