Although cancer cells differ in many ways from the cells of the host from which they arise, it has proved difficult to exploit these differences to improve diagnosis and treatment of solid malignancy. It has been known for some time that there are differences in the surface electrical potential of normal and malignant cells but until recently there have been no mechanisms available to measure these differences. With advances in electrode technology and the use of microprocessors to control and record direct current, it has proved possible to measure the differences in potentials to normal and malignant tissues. These differences can be measured at the skin surface of organs such as the breast. This book reports early results on measuring the skin potential of patients with benign and malignant breast disease and indicates that this technique could have considerable clinical impact. Differences in skin potential are demonstrated in both symptomatic and screened patients with breast cancer. Further investigation of this new non-invasive technique is clearly warranted.

Klappentext

The European School of Oncology came into existence to respond to a need for information, education and training in the field of the diagnosis and treatment of cancer. There are two main reasons }Vhy such an initiative was considered necessary. Firstly, the teaching of oncology requires a rigorously multidisciplinary approach which is difficult for the Universities to put into practice since their system is mainly disciplinary orientated. Secondly, the rate of technological development that impinges on the diagnosis and treatment of cancer has been so rapid that it is not an easy task for medical faculties to adapt their curricula flexibly. With its residential courses for organ pathologies and the seminars on new techniques (laser, monoclonal antibodies, imaging techniques etc.) or on the principal therapeutic controversies (conservative or mutilating surgery, primary or adjuvant chemotherapy, radiotherapy alone or integrated), it is the ambition of the European School of Oncology to fill a cultural and scientific gap and, thereby, create a bridge between the University and Industry and between these two and daily medical practice. One of the more recent initiatives of ESO has been the institution of permanent study groups, also called task forces, where a limited number of leading experts are invited to meet once a year with the aim of defining the state of the art and possibly reaching a consensus on future developments in specific fields of oncology.

Inhalt

Underlying Mechanisms Involved in Surface Electrical Potential Measurements for the Diagnosis of Breast Cancer: An Electrophysiological Approach to Cancer Diagnosis.- A History of Direct Current Measurement as it Relates to Tissue Proliferation.- Initial Preclinical Experiments with the Electropotential Differential Diagnosis of Mammary Cancer.- Dedicated Systems for Surface Electropotential Evaluation in the Detection and Diagnosis of Neoplasia.- Is There a Need for a New Detection Technique for Breast Cancer?.- Breast Biophysical Examination (BBE): Potential Applications in Clinical Practice.- Use of Non-Directed (Screening) Arrays in the Evaluation of Symptomatic and Asymptomatic Breast Patients.- The Value of BBE in the Assessment of Breast Lesions.- Multicentre Clinical Trials Evaluating the Breast Biophysical Examination in the Assessment of Breast Disease.