Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury 2

Over one hundred contributions detail advances in the molecular and cellular biology of eicosanoid production, as well as their role in signal transduction. One of the most exciting developments explored within this collection of articles is the expression of the novel isoform of cyclooxygenase (cox-2), which may play a large role in the development of anti-inflammatory drugs.

Inhalt

A: Phospholipases: Regulation of Phosphoinsitide Phospholipases by G-Proteins; J. Exton. Biosynthetic Enzymes: (S)-Type Lipoxygenase and Cyclooxygenase Reaction Box Models Characterizing the Stereochemistry of the Dioxygenation Reaction W. Lehman. Receptors:Dual Effect of Propanonol on the Human Platelet Activation of Thrombin: Potentiation of Free Intracellular Ca2+ Mobilization and Inhibition of Phospholipase D Activity; S. Svetlov. Protein Kinases/Phosphatases: Diacylglycerol Second Messengers: Molecular Switches in Growth Control; R. Bell. Inhibitors of Bioactive Lipids and Signal Transduction: Carcinogenesis: Cell Growth I: Part B: Apoptosis and Differentiation: Radiation-Induced Apoptosis in Tumors: Effects of Radiation Modulating Agents; L. Milas. Cytokines and Bioactive Lipids in Inflammation: Effects of GM-CSF on Leukotriene B4 Synthesis in Human Neutrophils: Facilitation of the Priming Effect by Autologous Plasma; E. Krump. Cell Motility and Cytoskeletal Alterations: Apoptosis in Tumor Biology and Therapy; R. Meyn. Adhesion Mechanisms in Inflammation and Metastasis: Radioprotection and Radiosensitization: Dietary Modulation and Prevention: Clinical Studies. 121 additional Articles. Index