Interest in the ability of myocardium to adapt to ischaemic stress has continued to grow since the discovery of ischaemic preconditioning in 1986. In 1993, two reports heralded the recognition of a delayed preconditioning response in the heart, now commonly known as the `second window' of protection. Since then, a number of studies have described the ability of delayed preconditioning and related adaptive phenomena to protect against a variety of pathologies in the ischaemic and reperfused myocardium. Our understanding of the cellular mechanisms of sub-acute adaptive cardioprotection has advanced considerably during this period. This compilation of state-of-the-art reviews by those who have made significant contributions to this field provides detailed and critical analysis of this research, from molecular basis to potential clinical relevance. The book aims to provide an authoritative, comprehensive and thoroughly up-to-date overview for scientists and clinicians engaged in, or observing, this rapidly-developing area of heart research. It will also be of interest to those engaged in research on other tissues where ischaemia-reperfusion pathology is of major concern.

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Preface. 1. Delayed Preconditioning Against Lethal Ischaemic Injury; G.F. Baxter, D.M. Yellon. 2. Delayed Preconditioning Against myocardial Stunning; R. Bolli, et al. 3. Delayed Preconditioning Against Endothelial Dysfunction; V. Richard, et al. 4. Delayed Preconditioning Against Ventricular Arrhythmias; A. Vegh, J.R. Parratt. 5. Intracellular Signalling Mechanisms in Myocardial Adaptation to Ischaemia; D.K. Das. 6. Changes in Cardiac Gene Expression After Ischaemia and Reperfusion; L.V. Mayne. 7. The Heat Shock Response and Tissue Protection; R.W. Currie, J.-C.L. Plumier. 8. Antioxidant Defences in Myocardial Adaptation; N. Yamashita, et al. 9. Endotoxin, Monophosphoryl Lipid A and Delayed Cardioprotection; G.J. Gross. 10. Adenosine and Delayed Cardioprotection; A. Dana, et al. 11. Angina and Cardiac Adaptation; F. Ottani, et al. Index.