Pain in Osteoarthritis

An authoritative investigation of the sources and treatment of osteoarthritic joint pain

Millions of people throughout the world suffer from osteoarthritis (OA)--a medical condition causing its sufferers excruciating pain that is often disabling. This is the first book to offer clinicians an in-depth understanding of the biological sources of osteoarthritic pain and how they can be treated. Here, a team of leading international authorities has contributed state-of-the-art information on:

• The Neuroscience of Articular Pain--spinal and peripheral mechanisms of joint pain; experimental models for the study of osteoarthritic pain; inflammatory mediators and nociception in arthritis; phantoms in rheumatology; and more

• Osteoarthritis and Pain--joint mechanisms and neuromuscular aspects of OA; bone pain and pressure in OA joints; structural correlates of OA pain; and more

• Treatment of Osteoarthritic Pain--general approaches to treatment; treatments targeting pain receptors; treatments targeting biomechanical abnormalities; and treatments targeting inflammation

Whether you're a medical professional, researcher, student, or a generalist or specialist focusing on pain or arthritis, this is your one-stop reference for understanding and treating joint pain in osteoarthritis.

Autorentext

David T. Felson, Clinical Epidemiology Unit, Boston University School of Medicine, Boston, Massachusetts, USA. Hans-Georg Schaible, Institute of Physiology, University Hospital of Jena, Jena, Germany.

Zusammenfassung
An authoritative investigation of the sources and treatment of osteoarthritic joint pain Millions of people throughout the world suffer from osteoarthritis (OA)—a medical condition causing its sufferers excruciating pain that is often disabling. This is the first book to offer clinicians an in-depth understanding of the biological sources of osteoarthritic pain and how they can be treated. Here, a team of leading international authorities has contributed state-of-the-art information on:

• The Neuroscience of Articular Pain—spinal and peripheral mechanisms of joint pain; experimental models for the study of osteoarthritic pain; inflammatory mediators and nociception in arthritis; phantoms in rheumatology; and more
• Osteoarthritis and Pain—joint mechanisms and neuromuscular aspects of OA; bone pain and pressure in OA joints; structural correlates of OA pain; and more
• Treatment of Osteoarthritic Pain—general approaches to treatment; treatments targeting pain receptors; treatments targeting biomechanical abnormalities; and treatments targeting inflammation Whether you're a medical professional, researcher, student, or a generalist or specialist focusing on pain or arthritis, this is your one-stop reference for understanding and treating joint pain in osteoarthritis.

Inhalt
Preface vii

Acknowledgments ix

Contributors xi

Part I The Neuroscience of Articular Pain

1 Spinal Mechanisms Contributing to Joint Pain 3
Hans-Georg Schaible

2 Activation of Sensory Neurons in the Arthritic Joint 25
Blair D. Grubb

3 Changes in the Neural Substrate of Nociception in a Rat Derangement Model of Osteoarthritis 39
James L. Henry

4 Inflammatory Mediators and Nociception in Osteoarthritis 55
Bruce L. Kidd, Jason J. McDougall, and Julia J. Inglis

5 Phantoms in Rheumatology 73
Candida S. McCabe, Richard C. Haigh, Nicholas G. Shenker, Jenny Lewis, and David R. Blake

6 Mechanisms That Generate and Maintain Bone Cancer Pain 97
Juan Miguel Jimenez-Andrade, Monica Herrera, and Patrick W. Mantyh

7 Symmetry, T-Cells, and Neurogenic Arthritis 117
Nicholas G. Shenker, David R. Blake, Candida S. McCabe, Richard C. Haigh, and Paul I. Mapp

Part II Osteoarthritis and Pain

8 Joint Mechanics in Osteoarthritis 133
Walter Herzog, Douglas Bourne, and Aliaa Rehan Youssef

9 Neuromuscular Aspects of Osteoarthritis 157
Kenneth D. Brandt

10 Pressure-Driven Intravasation of Osseous Fat in the Pathogenesis of Osteoarthritic Pain 175
Peter A. Simkin

11 Structural Correlates of Osteoarthritis Pain: Lessons From Magnetic Resonance Imaging 185
Philip G. Conaghan

12 Evidence of Sensitization to Pain in Human Osteoarthritis 199
Gunnar Ordeberg

13 Current Perspectives on the Clinical Presentation of Joint Pain in Human Osteoarthritis 211
Paul Creamer

Part III Treatment of Osteoarthritic Pain

14 General Approach to Treating Osteoarthritic Pain: Targeting Biomechanics Inflammation and Nociception 229
David T. Felson

15 Neurobiological Mechanisms of Osteoarthritic Pain and Analgesic Treatment 233
Tuhina Neogi and Joachim Scholz

16 Exercise, Taping, and Bracing as Treatments for Knee Osteoarthritis Pain 255
Kim Louise Bennell, Michael Anthony Hunt, and Rana Shane Hinman

17 Treating Inflammation to Relieve Osteoarthritic Pain 285
David T. Felson

Index 295