Cytokines and Mental Health explores the relationship between cytokines, neural circuitry and mental health. It is interdisciplinary and "translational", bringing together information that spans the spectrum from the molecular and cellular levels to the patient and the clinic. Content includes chapters that discuss cytokine pathways in the brain, the neurochemical and neuroendocrine effects of cytokines, and the behavioral effects of cytokines including sickness behavior. These chapters in basic research are followed by a more clinical section that discusses the role of cytokines in neuropsychiatric disorders such as major depression, schizophrenia and Alzheimer's disease. The book offers different things to different people. It should be of great interest to neuroscientists and immunologists working in the field of psychoneuroimmunology. It would also greatly benefit mental health professionals including psychiatrists, psychologists and clinicians of diverse background who are interested in mind-body medicine.

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List of Contributors. Preface. Acknowledgements. I: Brain Effects of Cytokines: Relevance to Mental Illness. 1. Cytokines and Cytokine Receptors: Principles of Action; D.G. Remick. 2. Immunosensory Signaling: Role of Cytokines; L.E. Goehler. 3. Cytokine Pathways in the Brain; J. Licinio, Ma-Li Wong. 4. Effects of Cytokines on Cerebral Neurotransmission and Potential Relationships to Function; A.J. Dunn. 5. Cytokines and HPA Axis Regulation; M.N. Silverman, et al. 6. Cytokines and Neuropeptides; N.P. Plotnikoff, et al. II: Behavioral Effects of Cytokines. 7. Cytokines and Sickness Behavior; R. Dantzer. 8. Cytokines and Sleep Regulation; J.M. Krueger, L. Churchill. 9. Cytokines and Appetite; W. Langhans, B.J. Hrupka. 10. Cytokines Effects on Learning and Memory; J.M. Petitto, et al. 11. Cytokine-elicited Sensitization: Neuroendocrine, Neurotransmitter and Behavioral Responses; S. Hayley, et al. III: Cytokines and Neuropsychiatric Disorders. 12. Cytokine Regulation in Major Depression; Z. Kronfol. 13. Cytokine Regulation in Anxiety Disorders; F. Brambilla. 14. Cytokines and Post Traumatic Stress Disorder; D.G. Baker, et al. 15. Cytokines and Schizophrenia; T. Pollmächer, et al. 16. Cytokine Regulation in Autism; V.K. Singh. 17. Cytokine Regulation in Alzheimer's Disease; R.E. Mrak. 18. Cytokines, Immunity and Disordered Sleep; M. Irwin. Index.