Corneal Regeneration

This text provides expert instruction on the varying surgical techniques currently employed for the regeneration of the ocular surface. Corneal Regeneration: Therapy and Surgery begins with a thorough discussion of current research based on data obtained in clinical human studies, and discusses the potential clinical implications for this promising new stage of eye surgery. Sections devoted to the stem cell, regenerative surgery and therapy of the ocular surface epithelium, corneal stroma, and corneal endothelium follow, each section comprehensively covering applied anatomy, current therapy and regenerative techniques, with a look to future directions of the field including eventual cell therapy.

Corneal Regeneration: Therapy and Surgery is the first book of its kind, systematically covering the developments the medical community has achieved in corneal regeneration from all angles. Written and edited by leading experts in the field, researchers and ophthalmologists alike will find this to be a unique source of information on corneal regeneration, as well as a thoughtful reflection on potential applications of regenerative surgery in ophthalmology as a whole.

Autorentext
Prof. Dr Jorge Alió has been Professor and Chairman of Ophthalmology since 1987, first at the University of Alicante and since 2002 at the University Miguel Hernandez de Elche, also in Alicante, Spain. Dr. Alió has been deeply involved since the beginning of his professional career in Academic and Research activities in combination with an intense clinical and surgical practice. His main dedication has been to Cataract, Cornea and Refractive Surgery, even though within the broad basis of his medical education he has been involved in other areas such as Ocular Inflammation (uveitis), Vitreoretinal diseases and Strabismus surgery. The activities of Dr. Alió are currently mainly oriented on an international basis and he has contributed to the organization, funding and dissemination of different international and Spanish scientific societies. He has collaborated in the organization of many international and Spanish symposiums and congresses, such as the International Ocular Inflammation Society ( IOIS ) the European Society of Cataract and Refractive Surgery ( ESCRS ), The American Academy of Ophthalmology (AAO) the International Society of Refractive Surgery ( ISRS) and the World Ophthalmology Congress ( WOC ) among many others. He has been the author or co-author of 440 peer review papers published in prestigious international scientific journals, 241 book chapters, 78 books (as editor or co-editor), over 200 collaborations in ophthalmic scientific journals and over 1800 presentations and invited lectures in international meetings.

Inhalt

Part 1. Corneal Regeneration: The Concept, the Facts, the Potential

Chapter 1: Corneal Anatomy

Chapter 2: Corneal Healing

Chapter 3: Corneal Tissue Engineering

Part 2. The Stem Cell

Chapter 4: Stem Cells: Concept, Properties, and Characterization

Chapter 5: Corneal Stem Cells: Identification and Methods of Ex Vivo Expansion Chapter 6: Corneal Epithelial Stem Cells : Methods for Ex Vivo Expansion

Chapter 7: Corneal Stromal Stem Cell: Methods for Ex Vivo Expansion

Chapter 8: Corneal Endothelial Cells: Methods for Ex Vivo Expansion

Chapter 9: Corneal Regeneration: Use of Extracorneal Stem Cells

Chapter 10: One Cell, Two Phenotypes: Capturing Pluripotency for Corneal Regeneration

Chapter 11: Corneal Stem Cell Based Therapies

Part 3. Regenerative Surgery and Therapy of the Ocular Surface Epithelium

Chapter 12: Ocular Surface Epithelium: Applied Anatomy

Chapter 13: Classical Techniques for Limbal Transplantation

Chapter 14: Simple Limbal Epithelial Transplantation: An Update

Chapter 15: Cell Therapy Using Ex Vivo Cultured Limbal Cells: CLET and Equivalent

Chapter 16: Cell Therapy Using Cultivated Oral Mucosal Epithelial Transplant (COMET)

Chapter 17: Cell Therapy Using Extraocular Mesenchymal Stem Cells

Chapter 18: Cell Therapy Using Induced Pluripotent Stem Cells

Chapter 19: Cultivated Limbal Stem Cell Transplantation: Indications and Technique

Chapter 20: Optimizing the Ocular Surface for Regenerative Surgery: What is Important and What is Essential for the Outcome

Chapter 21: Stem Cell Spheres for Corneal Regeneration

Chapter 22: Platelet Rich Plasma (E-PRP) for Corneal Regeneration

Part 4. Regenerative Surgery of the Corneal Stroma

Chapter 23: Corneal Stroma: Applied Anatomy

Chapter 24: Adipose Stem Cells for Stromal Expansion in Keratoconus: Confocal Microscopic Evaluation

Chapter 25: Limbal Stromal Stem Cells in Corneal Wound Healing: Perspective and Current Update

Chapter 26: Cell Therapy of the Corneal Stroma Using Ex Vivo Cultured Extraocular Cells

Part 5. Regenerative Surgery of the Corneal Endothelium

Chapter 27: Corneal Endothelium: Applied Anatomy

Chapter 28: Corneal Endothelium: Isolation and Cultivation Methods

Chapter 29: Corneal Endothelial Cell Transplantation: Animal Models

Chapter 30: Cell Based Therapy for Corneal Endothelial Regeneration

Chapter 31: Corneal Endothelium Regeneration: Future Prospects

Chapter 33: Dysfunctional Corneal Endothelium: Delivery of Cell Therapy