A comprehensive account of genomic rearrangement, focusing on the mechanisms of inversion, translocation, gene and genome duplication and gene transfer and on the patterns that result from them in comparative maps. Includes analyses of genomic sequences in organelles, prokaryotes and eukaryotes as well as comparative maps of the nuclear genomes in higher plants and animals. The book showcases a variety of algorithmic and statistical approaches to rearrangement and map data.

Inhalt

Preface. Foreword; W.F. Doolittle. Introduction. Comparative Genomics; D. Sankoff, J.H. Nadeau. 1. Mechanisms. Cytogenetics, Molecular Genetics, Population Genetics. 2. Organelles: Mitochondria and Chloroplast. Rearrangements in Small Genomes. 3. Combinatorial Algorithms. A New Set of Problems for a New Kind of Data. 4. Prokaryotes. Genome Scrambling versus Functional Clustering. 5. Statistics. The Quantification of Comparative Mapping. 6. Nuclear Genomes. Evolutionary Inference from Comparative Mapping. 7. Gene and Genome Duplication and Multi-gene Families. How Can Duplication by Analyzed?