A distinguished international panel of authors define our current understanding of neuronal damage after ischemia and critically review the significant recent developments and progress in cerebrovascular accident (CVA) drug trials, both in animal models and in the clinical setting. These leading basic and fundamental authorities survey such important new drugs as calcium-influx inhibitors, free-radical scavenging drugs, glutamate and glycinergic antagonists, and immune suppressors. They also evaluate all the latest findings concerning calcium homeostasis, glutamate toxicity, gene activation, and the role of free radicals, glycine, and hormones. Chapters devoted to the neuroimaging of stroke, clinical trials, and the role of cerebral immune activation complete this informative collection of cutting-edge reviews.

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Stroke: Prevalence and Mechanisms of Cell Death, Gert J. Ter Horst and Antonio Postigo. Imaging of Stroke, Henk Stevens, Hugo M. L. Jansen, Jacques DeReuck, and Jakob Korf. Clinical Aspects of Stroke and Therapeutic Strategies, Keith W. Muir, Elkan Gamzu, and Kennedy R. Lees. Calcium Homeostasis, Nimodipine, and Stroke, Paul G. M. Luiten, Bauke Stuiver, Gineke I. de Jong, Csaba Nyakas, and Jacques H. A. De Keyser. Glutamate Neurotoxicity and Stroke, Tihomir P. Obrenovitch. Glycine Antagonists for Treatment of Ischemic Brain Injury, Midori A. Yenari, David C. Tong, and Gregory W. Albers. Free Radical-Mediated Cerebral Damage After Hypoxia/Ischemia and Stroke, Tomohiro Matsuyama. Genomic Responses Following Cerebral Ischemia, Christoph Wiessner and Konstantin-Alexander Hossmann. Hormonal Modulators of Cerebral Ischemia, Laura J. McIntosh and Robert M. Sapolsky. Inflammatory Responses to Cerebral Ischemia: Implications for Stroke Treatment, John Sharkey, John S. Kelly, and Steven P. Butcher. Animal Models Used in Cerebral Ischemia and Stroke Research, Akira Tamura, Kensuke Kawai, and Kiyoshi Takagi. Index.