Over the past two decades, there has been a steady increase in knowledge associated with the clinical manifestations of cholestatic liver disease. In addition to a growing amount of information on the well-studied disorders of primary biliary cirrhosis and primary sclerosing cholangitis, there has been a rapid accumulation of data on less well-known but important topics such as overlap syndromes with autoimmune hepatitis, cholestatic variants of alcohol and viral disease, and cholestasis following liver transplantation. These emerging insights are complemented by further improvements of the diagnosis and management of cholestasis.

Based on these clinical situations, Cholestatic Liver Disease provides useful information for individuals involved in the care of patients affected by aspects of cholestatic liver disease and supplies scientific updates from leading experts that relate to the clinical evaluation and management of cholestatic liver disorder.

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Diagnosis of cholestasis Liver tests/antibodies.- Drug-induced cholestasis Include herbal remedies.- PBC Usual (overlap and recurrence after transplant covered elsewhere).- PSC Usual (overlap and recurrence after transplant covered elsewhere) Risk of colon CA with IBD, colon CA post-transplant, and cholangiocarcinoma.- Overlap Syndrome with autoimmune hepatitis.- Rare causes of cholestasis (genetic disorders).- Cholestatic variants of alcohol, viral disease Alcohol Hepatitis (viral).- Cholestasis from systemic disorders Sarcoid, lymphoma, granulomatous disease, cystic fibrosis, rheumatologic diseases.- Complications of cholestasis Osteoporosis Pruritus Lipids.- Cholestasis post transplantation Drugs, strictures, viral disease, recurrent cholestatic liver disease.