Enzyme-Based Organic Synthesis

Enzyme-Based Organic Synthesis

An insightful exploration of an increasingly popular technique in organic chemistry

In Enzyme-Based Organic Synthesis, expert chemist Dr. Cheanyeh Cheng delivers a comprehensive discussion of the principles, methods, and applications of enzymatic and microbial processes for organic synthesis. The book thoroughly explores this growing area of green synthetic organic chemistry, both in the context of academic research and industrial practice.

The distinguished author provides a single point of access for enzymatic methods applicable to organic synthesis and focuses on enzyme catalyzed organic synthesis with six different classes of enzyme. This book serves as a link between enzymology and biocatalysis and serves as an invaluable reference for the growing number of organic chemists using biocatalysis.

Enzyme-Based Organic Synthesis provides readers with multiple examples of practical applications of the main enzyme classes relevant to the pharmaceutical, medical, food, cosmetics, fragrance, and health care industries.

Readers will also find:

• A thorough introduction to foundational topics, including the discovery and nature of enzymes, enzyme structure, catalytic function, molecular recognition, enzyme specificity, and enzyme classes

• Practical discussions of organic synthesis with oxidoreductases, including oxidation reactions and reduction reactions

• Comprehensive explorations of organic synthesis with transferases, including transamination with aminotransferases and phosphorylation with kinases

• In-depth examinations of organic synthesis with hydrolases, including the hydrolysis of the ester bond

Perfect for organic synthetic chemists, chemical and biochemical engineers, biotechnologists, process chemists, and enzymologists, Enzyme-Based Organic Synthesis is also an indispensable resource for practitioners in the pharmaceutical, food, cosmetics, and fragrance industries that regularly apply this type of synthesis.

Autorentext

Cheanyeh Cheng, PhD, obtained his doctorate from the Department of Chemical and Biochemical Engineering at Rutgers University in 1987 and is Professor of Chemistry at Chung Yuan Christian University in Taiwan. His research covers the fields of bioorganic chemistry and biotransformation, analytical chemistry, and biosensors. He owns 15 patents from Taiwan, the United States of America, Japan, and the European Union.

Klappentext

An insightful exploration of an increasingly popular technique in organic chemistry

In Enzyme-Based Organic Synthesis, expert chemist Dr. Cheanyeh Cheng delivers a comprehensive discussion of the principles, methods, and applications of enzymatic and microbial processes for organic synthesis. The book thoroughly explores this growing area of green synthetic organic chemistry, both in the context of academic research and industrial practice. The distinguished author provides a single point of access for enzymatic methods applicable to organic synthesis and focuses on enzyme catalyzed organic synthesis with six different classes of enzyme. This book serves as a link between enzymology and biocatalysis and serves as an invaluable reference for the growing number of organic chemists using biocatalysis. Enzyme-Based Organic Synthesis provides readers with multiple examples of practical applications of the main enzyme classes relevant to the pharmaceutical, medical, food, cosmetics, fragrance, and health care industries. Readers will also find:

• A thorough introduction to foundational topics, including the discovery and nature of enzymes, enzyme structure, catalytic function, molecular recognition, enzyme specificity, and enzyme classes
• Practical discussions of organic synthesis with oxidoreductases, including oxidation reactions and reduction reactions
• Comprehensive explorations of organic synthesis with transferases, including transamination with aminotransferases and phosphorylation with kinases
• In-depth examinations of organic synthesis with hydrolases, including the hydrolysis of the ester bond Perfect for organic synthetic chemists, chemical and biochemical engineers, biotechnologists, process chemists, and enzymologists, Enzyme-Based Organic Synthesis is also an indispensable resource for practitioners in the pharmaceutical, food, cosmetics, and fragrance industries that regularly apply this type of synthesis.

Zusammenfassung
Enzyme-Based Organic Synthesis An insightful exploration of an increasingly popular technique in organic chemistry In Enzyme-Based Organic Synthesis, expert chemist Dr. Cheanyeh Cheng delivers a comprehensive discussion of the principles, methods, and applications of enzymatic and microbial processes for organic synthesis. The book thoroughly explores this growing area of green synthetic organic chemistry, both in the context of academic research and industrial practice. The distinguished author provides a single point of access for enzymatic methods applicable to organic synthesis and focuses on enzyme catalyzed organic synthesis with six different classes of enzyme. This book serves as a link between enzymology and biocatalysis and serves as an invaluable reference for the growing number of organic chemists using biocatalysis. Enzyme-Based Organic Synthesis provides readers with multiple examples of practical applications of the main enzyme classes relevant to the pharmaceutical, medical, food, cosmetics, fragrance, and health care industries. Readers will also find:

• A thorough introduction to foundational topics, including the discovery and nature of enzymes, enzyme structure, catalytic function, molecular recognition, enzyme specificity, and enzyme classes
• Practical discussions of organic synthesis with oxidoreductases, including oxidation reactions and reduction reactions
• Comprehensive explorations of organic synthesis with transferases, including transamination with aminotransferases and phosphorylation with kinases
• In-depth examinations of organic synthesis with hydrolases, including the hydrolysis of the ester bond Perfect for organic synthetic chemists, chemical and biochemical engineers, biotechnologists, process chemists, and enzymologists, Enzyme-Based Organic Synthesis is also an indispensable resource for practitioners in the pharmaceutical, food, cosmetics, and fragrance industries that regularly apply this type of synthesis.

Inhalt
Preface

Acknowledgements

Chapter 01 Introduction

1.1 Discovery and nature of enzyme

1.2 Enzyme structure and catalytic function

1.2.1 Enzyme structure

1.2.2 Catalytic function

1.3 Cofactors and coenzymes

1.4 Molecular recognition and enzyme specificity

1.4.1 Substrate specificity

1.4.2 Regiospecificity

1.4.3 Stereo-specificity

1.5 Enzyme classes and nomenclature

1.6 Enzyme and green chemistry

Chapter 02 Organic Synthesis with Oxidoreductases

2.1 Oxidation reactions

2.1.1 Oxidation of alcohols and aldehydes

2.1.2 Hydroxylation of alkanes

2.1.3 Hydroxylation of aromatic compounds

2.1.4 Dihydroxylation of aromatic compounds

2.1.5 Epoxidation

2.1.6 Sulfoxidation reactions

2.1.7 Baeyer-Villiger reactions

2.1.8 Peroxidation reactions

2.2 Reduction reactions

2.2.1 Reduction of aldehydes and ketones

2.2.2 Reduction of C=C bonds

Bibliography

Chapter 3 Organic Synthesis with Transferases

3.1 Transamination with Aminotransferases

3.2 Glycosyl-transfer with glycosyltransferase

3.3 Phosphorylation with kinases

3.4 Acetyl group transfer with acetyltransferase

Bibliography

Chapter 4 Organic Synthesis with Hydrolases

4.1 Hydrolysis of ester bond

4.1.1 Ester hydrolysis with esterases

4.1.2 Ester hydrolysis with lipases

4.1.3 Ester hydrolysis with proteases

4.2 Hydrolysis of amide bond

4.3 H…