Cell Division Machinery and Disease

This book critically evaluates the causal link between cell division machinery and disease. Further, it identifies key open questions in the field and the means for exploring them. Throughout the various chapters, internationally known contributors present the evidence for and against a causal link between key elements of the cell division machinery and diseases such as cancer, neuropathologies, aging, and infertility. A more clinically oriented chapter further discusses the current and future applications of anti-mitotic drugs in these diseases. Cell Division Machinery and Disease is essential reading for graduate or advanced graduate students, researchers or scientists working on cell division as well as clinicians interested in the molecular mechanisms of the discussed diseases.

Autorentext
Monica Gotta is Ordinary Professor at the Medical Faculty of the University of Geneva. She has previously worked as a Swiss-National Science Foundation Professor at the ETH Zurich. Her research interests are the (a)symmetric cell divisions of C. elegans embryos and human cells. She has published 43 papers and 1 book chapter. She has also been awarded an EMBO YIP award.
Patrick Meraldi is Associate Professor at the Medical Faculty of the University of Geneva. He has previously worked as a Swiss-National Science Foundation Professor at the ETH Zurich. His research interest is primarily in the field of chromosome segregation in human cells. He has published 49 papers and 2 book chapters. He has also been awarded an EURYI award , an EMBO YIP award and the Walther Flemming Medal.

Inhalt

1.Meiotic divisions: no place for gender equality.- 2.Consequences of centrosome dysfunction during brain development.- 3.Dividing with extra centrosomes: a double edged sword for cancer cells.- 4.Kinetochore malfunction in human pathologies.- 5.The elephant in the room: the role of microtubules in cancer.- 6.Clinical development of anti-mitotic drugs in cancer.- 7.Mitotic dysfunction associated with aging hallmarks.- 8.Unbalanced Growth, Senescence and Aging.- 9.The spindle orientation machinery beyond mitosis: when cell specialization demands polarization.