Cardiac Markers is a comprehensive, up-to-date summary of clinical information on serum cardiac markers for coronary artery disease. This book reviews in detail the biochemistry, clinical significance, and analytical measurements for each marker, as well as the advantages and limitations of existing and proposed markers. Comprehensive descriptions of therapeutic approaches to manage patients are presented. Also included are up-to-date listings of primary references and commercial methodologies, the latest data on the pathophysiology of unstable angina, and a discussion of the new emergency-room chest pain centers. Anyone who needs to know how to examine, diagnose, treat, and manage patients with acute chest pain and heart attacks will find this book indispensable.

Inhalt

Part I: Clinical Aspects. Introduction to Coronary Artery Disease (CAD) and Biochemical Markers, Alan H. B.Wu . Pathophysiology of Acute Coronary Syndromes,Satyendra Giri, David D. Waters, and Alan H. B. Wu . Pathophysiology and Treatment of Acute Myocardial Ischemia and Infarction,Gary B. Green, Edward S. Bessman, and Sol F. Green . Markers of Myocardial Injury in the Evaluation of the Emergency Department Patient with Chest Pain, Gary B. Green and Sol F. Green . Ultrastructure of the Striated Muscle Cell, Robert G. McCord and Allen W. Clark . Part II: Cytoplasmic Markers. Myoglobin and Carbonic Anhydrase III, Hemant C. Vaidya and H. Kalervo Vaananen. Creatine Kinase, Isoenzymes, and Variants, Alan H. B. Wu. CK-MB Activity Assays, Alan H. B. Wu. CK-MB Measurements by Immunoassay, Sol F. Green. CK Isoforms, Sol F. Green. Lactate Dehydrogenase and Its Isoenzymes,Shan S. Wong. Part III: Structural Markers. Biochemistry and Molecular Biology of Troponins I and T, Kenneth J. Dean. Cardiac Troponin T as a Marker of Myocardial Injury, Kenneth J. Dean. Cardiac Troponin I,Fred S. Apple. Myosin Light and Heavy Chains, Mauro Panteghini. Part IV: Future Assay and Format. Point-of-Care Testing for Cardiac Markers, Robert H. Christenson. New Biochemical Markers for Heart Diseases, Alan H. B. Wu and Robert G. McCord. Index.