Carcinoma of the Cervix

Various scientific evaluations taken from these chapters were presented during the international symposium, 'Carcinoma of the Cervix,' which was held from September 4-7, 1980 in Kiawah Island, Charleston, South Carolina, U.S.A. An international selection of research investigators have contributed reviews designed to be informative to medical, graduate and post-graduate students, as well as clinicians, oncologists and investigators working in the area of female carcinoma. An attempt has been made to provide a total coverage of current progress in carcinoma of the cervix. In particular, the following major areas are included: Epidemiology, Histology & Histochemistry, Ultra­ structure, Physiology & Biochemistry, Genetics & Cytogenetics, Immunology, Diagnosis, and Patho­ physiology & Complications. Major changes have occurred in incidence and mortality rates for carcinoma of the cervix in the past decade. Mass screening programs and their ability to detect earlier stage diseases have attributed to a reduction in invasive diseases. Most cervical cancers could be prevented by an extension of cytologic screening programs in high risk areas. Greater resources must be provided to reach high risk areas in order to prevent the occurrence of cervical cancer.

Inhalt

I. Epidemiology.- 1. U.S. trends in carcinoma of the cervix: incidence mortality and survival.- 2. Mass screening for cervical cancer: strategies for reaching high risk women in an urban-industrial setting.- 3. Invasive carcinoma of the uterine cervix in women younger than 25 years.- 4. Cervical carcinoma in Panama.- 5. Cervical carcinoma detection and mortality in Chile.- 6. Cervical carcinoma in El Salvador.- 7. Cervical carcinoma in Kuwait.- 8. Abnormal cervical cytology in Jamaica.- II. Growth Patterns, Structure and Ultrastructure.- 9. Growth patterns of microinvasive carcinoma of the cervix.- 10. Growth, spread and grading in squamous cell carcinoma of the uterine cervix.- 11. Microinvasive carcinoma of the cervix: definition and behavior.- 12. Hyperkeratotic cervical dysplasia.- 13. Mucoepidermoid carcinoma of the cervix.- 14. Morphometric analysis of basal cell-stroma interface in normal and abnormal cervical epithelium.- 15. SEM of neoplasia of the cervical epithelium.- 16. Surface ultrastructure of the uterine cervix and early detection of irreversible neoplasia.- 17. Histochemistry of alkaline phosphatase in cervical neoplasia.- 18. Morphology of the basement membrane in carcinoma of the cervix.- III. Etiology.- 19. Role of sperm basic proteins as carcinogens in cervical cancer.- 20. Expression of herpes virus antigen in premalignant and malignant cervix.- 21. Immunological aspects of squamous cell carcinoma of the uterine cervix: use of leukocyte adherence inhibition assay.- 22. Human cell line (SKG-1) derived from epidermoid cancer of the cervix.- 23. Effect of oral contraceptives and IUDs on cervical carcinogenesis.- IV. Diagnosis and Prognosis.- 24. Diagnostic dilemma of recurrent cervical carcinoma.- 25. Prognostic factors in carcinoma of the cervix.- 26. Colposcopy and cytology for the diagnosis of early cervical carcinoma.- 27. Outpatient diagnosis and selection of treatment of cervical intraepithelial neoplasia using colposcopy.- 28. Adenocarcinoma of the cervix: histopathologic and clinical features.- 29. Distinction between cervical and endometrial adenocarcinoma with immunoperoxidase staining of carcinoembryonic antigen.- 30. Lymphography, angiography and phlebography in the staging and follow-up of cervical carcinoma.- 31. Concluding remarks: future research.