Cancer in Transplantation: Prevention and Treatment

Malignancies are frequent complications in organ transplantation, mainly as the result of infection with certain viruses and of long-term immunosuppression. The epidemiology confirms that the increased incidence concerns certain cancers, especially HIV-related skin cancers and EBV-related lymphoproliferative malignancies.
This book covers all currently available information on this important topic of the relationships between transplantation and malignancies: preexisting cancers, posttransplant cancers, their etiology and pathophysiology, their prevention and treatment. A significant part of the volume is devoted to prophylaxis, early detection and modern forms of therapy in posttransplant lymphomas. As a conclusion of all these new data, the theory of immunosurveillance deserves to be significantly modified.

Inhalt

Part One: Epidemiology. 1. Epidemiology of Cancer in Transplant Patients; I. Penn. 2. Multicenter Analysis of Posttransplant Malignancies; G. Opelz. 3. German Multicenter Analysis of Malignancies Following Renal Replacement Therapy in Children; A.M. Wingen. 4. Malignancies Transmitted with the Transplant; N. Lefrançois. Part Two: Malignancies Preexisting to Transplantation. 5. Outcome of Preexisting Urological Tumours in Dialysis and in Renal Transplant Recipients; G. Karam. 6. Screening for Breast and Gynaecologic Carcinomas in Transplant Patients; P. Mathevet. 7. Results of Renal Transplantation for Wilm's Tumour; M.F. Gagnadoux. 8. Prevention of recurrence after Liver Transplantation for Hepatocellular Carcinoma; H. Bismuth. Part Three: De Novo Malignancies After Transplantation. 9. Skin Cancers in Organ Transplant Recipients; S. Evurard. 10. Kaposi's Sarcoma in Organ Transplantation; J.L. Touraine. 11. Human T-Cell Leukemia Virus Type I (HTLV_I) and Transplantation; A. Bazarbachi. 12. Hepatitis B Virus and Primary Liver Cancer in Hepatitis B Surface Antigen Positive and Negative Patients; P. Paterlini. 13. Malignancies in Patients with Pancreas and Kidney Transplants; D. Cantarovich. Part Four: Immunosuppression and Cancer. 14. Cancer Risk Factors in Transplantation; E. Alamartine. 15. Risk of Cancer in Transplant Patients Treated with Recombinant Growth Hormone; P. Cochat. 16. Malignancies in Transplant Patients under Cyclosporine Treatment for More than 10 years;U. Frei. 17. Risk of Malignancies in Patients Treated with Sandimmun for Autoimmune Disease; V. Lamarque. 18. De Novo Malignancies Following Renal Transplantation; N. Yoshimura. Part Five: Epstein-Barr Virus Related Malignancies. 19. Virus Induced Cancer: The Lesson of Epstein-Barr Virus; M.G. Masucci. 20. Nonlymphoid Epstein-Barr Virus Induced Neoplasms after Organ Transplantation; P.S. Dickman. 21. The Epstein- Barr Virus Latency and Reactivation; A. Sergeant. 22. Earl Detection of EBV Infection and Meaning in Transplant Patients; E.B. Drouet. 23. Lymphomas in the scid/hu Mice: Effect of EBV on Human B-Cells in Vivo; J.L. Garnier. Part Six: Lymphoproliferative Syndromes after Transplantation. 24. Types of Lymphomas in Transplant and Other Immunosuppressed patients; M. Raphael. 25. Cytokines from Lymphoid Organs of HIV- Infected Patients: Production and Role of Cytokine sin Lymphoproliferations of Immune Deficiency; D. Emilie. 26. Interleukin 10 and non Hodgkin's Lymphomas; N. Voorzanger. 27. Serum Monoclonal Immunoglobulins in Renal Transplant Recipients: A Study Using High Resolution Electrophoresis and Western Blotting; G. Touchard. 28. Increased Risk of Lymphoproliferative Disorders Following the Use of Okts: Association with Cumulative Dose; L.J. Swinnen. 29. Clinical Characteristics of Lymphoproliferations after Renal Transplantation. Nantes Experience; J. Dantal. 30. Therapeutic Issues in Lymphoproliferative Disorder: Treatment and Outcome of 28 Cases Observed in a Single Center; V. Leblond. 31. Ant