Cancer Chemotherapy: Concepts, Clinical Investigations and Therapeutic Advances

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Inhalt

I. Concepts.- 1. Alkylating agents: Mechanisms and modulation.- 2. Reduced folates and fluoropyrimidine antitumor efficacy.- 3. Laboratory aspects of multidrug resistance.- II. Initial clinical investigations.- 4. Multidrug resistance: clinical findings and implications.- 5. Current status of trimetrexate, a folate antagonist with antineoplastic and antiprotozoal properties.- 6. Daunomycin and doxorubicin LYM-1-drug conjugates for the treatment of malignant lymphomas.- 7. Phase I trials: Role of the nurse investigator.- III. Therapeutic advances.- 8. The role of chemotherapy in the treatment of squamous cell tumors of the esophagus.- 9. Systemic chemotherapy of transitional cell carcinoma of the urothelium.- 10. Nasopharyngeal cancer, undifferentiated type: The medical oncologist's viewpoint.- 11. Primary central nervous system lymphomas.