Big on Bk: Current Insights into the Function of Large Conductance Voltage- and Ca2+- Activated K+ Channels at the Molecular, Cellular and Systemic Levels, a volume in the International Review of Neurobiology series, is a comprehensive overview of the state-of-the-art research into this area. It reviews current knowledge and understanding, and also provides a starting point for researchers and practitioners entering the field. - The latest volume in the International Review of Neurobiology series - Provides a broad coverage of subject matter at the molecular, cellular and systemic levels - Presents an ideal resource for researchers and practitioners, and those just entering the field

Inhalt

1. Biophysics of BK channel gating

Riccardo Olcese * 2. Modulation of BK channel function by auxiliary beta and gamma subunits * Jiusheng Yan * 3. Posttranscriptional and posttranslational regulation of BK channels * Mike Shipston * 4. Protein network interacting with BK channels * Hongkyun Kim * 5. Functional role of mitochondrial and nuclear BK channels * Tian-Ming Gao * 6. Modulation of BK channels by small endogenous molecules and pharmaceutical channel openers * Toshinori Hoshi * 7. Modulation of BK channels by ethanol * Alex Dopico * 8. BK channels in neurons * Alison Barth * 9. BK channels in the pituitary and hypothalamus * Peter Duncan * 10. BK channels in the inner ear * Sonja Pyott * 11. BK channels in the vascular system * Gayathri Krishnamoorthy-Natarajan * 12. Developing the molecular pharmacology of BK channels for therapeutic benefit * Gregory John Kaczorowski *