Applied Electrospray Mass Spectrometry

Discussing strategies to determine the structure and machanisms of numerous compound classics, this book covers new chemical and elctrophoretic techniques for rapid sample preconcentration and separation. It summarizes breakthroughs in the theory and instrumentation of electrospray mass spectrometry in pharmaceutical and biomedical applications, provides practical examples for the characterization of peptides, proteins, and glycoproteins, includes applications in proteomics, combinatorial chemistry, and drug characterization. Topics include chemical and electrophoretic techniques for rapid sample preconcentration and separation, screening processes for proteins from libraries of compounds, protein folding and dynamics, and more.

Autorentext

Birendra N. Pramanik (Edited by) , A. K. Ganguly (Edited by) , Michael L. Gross (Edited by)

Inhalt

Historical review/principles/instrumentation; nano-spray ESI development - LC/MS, CE/MS application; antibiotics/pharmaceuticals; pharmacokinetics/drug metabolism; proteins/peptides; glyco-proteins; proteomics/bioinformatics; noncovalent complexes;H/D exchange in solution; clinical biomedical application - micro-flow ESI.