Nearly thirty years ago, in 1974, the volume on Angiotensin edited by Irvine H.Page and F. Merlin Bumpus expanded the Handbook of Experimental Pharmacology. Even after two decades the multiplicity of its actions appears not to have been fully discovered. To call attention to its many functions is one of the purposes of this book. This new edition of the volume on Angiotensin attempts to provide an updated account of the knowledge and findings accumulated since the complexity of angiotensin was so accurately recognized.

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Part 4: Tissues .- Vascular.- Angiotensin II and Oxidative Stress. Angiotensin II and Atherosclerosis. Angiotensin II and Extracellular Matrix. Renin-Angiotensin Inhibitors and Vascular Effects. Brain / Nervous System.- Angiotensin Pathways and Brain Function. Involvement of the Renin-Angiotensin System in the Regulation of the Hypothalamic Pituitary Adrenol Axis. Angiotensin Actions on the Brain Influencing Salt and Water Balance. Angiotensin Receptor Signaling in the Brain: Ionic Currents and Neuronal Activity. Angiotensin, Neuroplasticity and Stroke.- Heart.- Role of Angiotensin II in Cardiac Remodeling. AT Receptor Pathophysiology in the Heart. Activation of the Renin-Angiotensin System after Myocardial Infarction.- Kidney and Adrenal Gland.- Angiotensin II, the Kidney and Hypertension. Angiotensin and Aldosterone Biosynthesis. Aldosterone - Clinical Aspects.- Part 5: Inhibition of the Renin-Angiotensin System.- ACE Inhibitors.- Interactions between the Renin-Angiotensin- and the Kallikrein-Kinin-Systems. ACE Inhibitors: Pharmacology.- AT1 Antagonists.- AT1 Receptor Antagonists : Pharmacology. Clinical Pharmacology of Angiotensin II Receptor Antagonists. Combined Blockade of the Renin Angiotensin System with ACE Inhibitors and AT1 Receptor Antagonists.- NEP/ACE Inhibitors.- Experimental and Clinical Aspects.- Part 6: Clinical Outlook.- Inhibitors of the RAS: Evidence-Based Medicine