Previous volumes in this series have discussed the current progression have identified a variety of targets and strategies state of our knowledge concerning the pathophysiology of to allow these goals to be realized. This volume critically cancer growth and progression. The complexity of the in reviews approaches towards cancer management in man at teraction of malignant neoplasms and the host, the the levels of: detection, diagnosis, surgery, radiology, heterogeneity of malignant cell subpopulations, and the chronobiology and endocrine treatment. existence of metastatic tumor cells resistant to drug thera Several chapters review selected methods of cancer diag pies remain as significant clinical challenges to clinical on nosis. In addition, a variety of on-going and novel ap cologists. Indeed, conventional treatment regimens of che proaches for cancer treatment are also presented in this volume. Progress in the early detection of malignant neo motherapy, surgery and radiology are often ineffective for the therapy of a large variety of established metastatic can plasms, coupled with novel approaches for the therapy of cer in patients. When one considers the insidiousness of such neoplasms, may ultimately yield safe and well-tolerated agents for the selective therapy of solid malignancies. New progressive neoplastic growth and the emergence of con tinuously more aggressive and malignant cellular subpop therapeutic approaches, directed towards the biochemical ulations one is overwhelmed with the challenges inherent in and molecular targets identified in the earlier volumes of this series, may ultimately lead to the generation of new mo attempting to control malignant neoplasms.

Inhalt

Selected diagnostic methods.- 2. Breast cancer diagnostic imaging.- 3. Stagnation of the treatment quota for certain neoplasms: A. Critical evaluation of contemporary anticancer methods.- 4. Stagnation of the treatment quota for certain neoplasms: B. Change in cancer treatment suggested by the analysis of metastatic growth.- 5. Neoplasm staging.- 6. From marker bioperiodicities, over marker rhythms, toward human cancer chronotherapy.- 7. Mammography.- 8. Thermography instead of mammography?.- 9. The chronobiologic pilot study with special reference to cancer research: Is chronobiology or, rather, its neglect wasteful?.- 10. Morphometry in cancer diagnostics.- 11. Principles and practice of surgical oncology: The influence of present day concepts of tumor biology.- 12. Radiation oncology.- 13. Hypoxic cell radiosensitizers.- 14. Heavy charged particles in cancer treatment.- 15. Intraoperative radiotherapy.- 16. Oxygen multistep immunostimulation as a simple process against cancer metastasis.- 17. Cancer multistep therapy: Principles and state of the art.- 18. Photosensitizers as diagnostic and therapeutic tools in oncology.- 19. Chronobiology, radiobiology and steps toward the timing of cancer radiotherapy.- 20. Endocrine therapy of breast cancer.- 21. Selected aspects of biological cancer therapy.- 22. Immunotherapy.- Index of subjects.