The Mucosal Immune System

This publication contains the proceedings of a Seminar on 'The Mucosal Immune System' held by the Commission of the European Communities (CEC) at the University of Bristol. School of Veterinary Science. Langford. Bristol on September 9th - 11th. 1960. The seminar formed part of the CEC programme of co-ordinated agricultural research on Protection of the Young Animal against Perinatal Disease and was organised by Professor F.J. Bourne and his colleagues Dr. T.J. Newby and Dr. C.R. Stokes. The Proceedings were edited by the organisers assisted by Janssen Services. 33a High Street. Chislehurst. Kent and provide an authoritative and up-to-date account of this rapidly moving research area. Serious economic loss from diseases of mucosal surfaces - particularly the enteric and respiratory tracts - occurs in young farm animals throughout the EEC. Protection against these diseases is based on an understanding of their epidemiology including host defence mechanisms. Mucosal vaccines have in the main given disappointing field results with. however. some notable exceptions. This seminar rationalises methods used to stimulate mucosal immune defence and indicates likely areas for future research and development. The CEC wishes to thank the organisers and the participants who con­ tributed to the success of the seminar. OPENING SESSION Chairman F.J. Bourne 3 OPENING REMARKS F.J. Bourne On behalf of the University of Bristol and the European Economic Community my colleagues and I welcome you to the Langford Veterinary School.

Contenu

Opening Session.- Opening Remarks.- Mucosal Immunity.- Session I: IgA Secretion and Transport.- Comparative Aspects of Secretory Immunity: The Transport of Heterologous IgA from Blood to Bile in Experimental Animals.- Discussion.- Binding, Uptake and Processing of Polymeric IgA by Cultured Rat Hepatocytes.- Discussion.- Epithelial Transport of Human Secretory Immunoglobulins.- Discussion.- Session II: Hypersensitivity Reactions in the Gut.- Induction and Expression of Mucosal Cell Mediated Immunity.- Discussion.- Stimulation and Suppression of IgE Antibodies by Antigens Presented to Mucosal Surfaces.- Discussion.- Food Antigen Handling and Immune Complex Formation in Healthy and Allergic Individuals.- Discussion.- An Animal Model of Anaphylactic Peptic Ulceration - A New Approach to Ulcer Disease in Humans?.- Discussion.- Gastrointestinal Hypersensitivity in the Preruminant Calf.- Discussion.- Altered Immune Function Associated with Dietary Factors.- Discussion.- Session III: Immune Response to Micro-Organisms and Protection.- Passive Immunity Against Enteric Viral Infections of Piglets.- Discussion.- Induction of an Interferon Activity in the Nasal Mucus of Calves by Administration of Inactivated IBR Virus and Levamisole.- Discussion.- Kinetics of Intestinal Antibody Development in Calves after Infection with Bovine Rotavirus.- Discussion.- Immune Response to Subunit Vaccines Against Enveloped Viruses.- Discussion.- Importance of Local Antibody in Resistance to Mycoplasma Infections of the Respiratory Tract.- The Mammary Gland Immune Response and Its Relationship to Intestinal Antigenic Exposure.- Discussion.- The Immune Response Following Oral Vaccination with E. Coli.- Discussion.- The Role of Mucus Secretions in the Protection of the Gastrointestinal Mucosa.- Discussion.- Mucus Secretion in the Gut, Its Relationship to the Immune Response in Nippostrongylus-Infected Rats.- Discussion.- Closing Session.- Immunoglobulin Serum Levels and Population of Intestinal IgA Plasma Cells in Normal and Immuno-Deficient (Nude - Neonatally Mu Suppressed - Neonatally Delta Suppressed) Rats.- The Experimental Basis for Oral Immunisation Against Cholera.- Short Communication.- Short Communication.- Discussion.- Short Communication.- Discussion.- Summary.- Poster Presentations.- Homing of Lymphocytes after Oral Vaccination of the Sow.- Immune Mechanisms in the Respiratory Tract.- Changes of Systemic Hypersensitivity Due to Enterally Applied Antigen.- Aerogenic Vaccination with Live Bacteria - Immune Reactions of Gnotobiotic Piglets Against Erysipelas.- List of Participants.