Résumé
Frontmatter -- Preface -- ACKNOWLEDGEMENTS -- PARTICIPANTS -- Contents -- The Gowland Hopkins Lecture: Transport of Folate and Pterin Compounds -- Chemical Aspects (1) -- Scottish International Education Trust Lecture: Synthetic Methods in Pteridine Chemistry: Some Applications to Pteridine Natural Products -- Synthesis, Chemical and Enzymatic Properties, and Therapeutic Potential of 6,6-Disubstituted Tetrahydroand Quinoid-Dihydro-Pterins -- The Structure of Quinonoid Dihydropterins [2-Amino-7,8(6H)-Dihydropteridin-4-ones] -- Some Simple s-Triazolopteridines -- Linear Tricyclic Analogs of Pteridines -- Reactions of Furazano [3,4-djPyrimidines and their Application to Pteridine Synthesis -- Syntheses of some Blocked 7,8-Dihydropteridines -- Synthesis of Chiral Reduced Pteridine Coenzymes -- Report on Discussions -- Chemical Aspects (2) -- Reactivity of Pteridines -- Synthesis and Antitumor Activity of 10-Deazaminopterins -- Synthesis and Biological Activity of 5-Deazafolic Acid and 5-Deazaaminopterin -- The Nor-Analogues of Folic Acid -- Report on Discussions -- Neurochemical and Clinical Aspects -- Metabolism of Pteridine Cofactors in Neurochemistry -- Pteridines in Cancer and Other Diseases -- Dihydropteridine Reductase Activity in Human Breast Cancer. Studies of 580 Cases and Correlations with Hormone Receptors and Cellular Typing -- A Critical Appraisal of Methods for the Quantitative Analysis of Tetrahydrobiopterin, Dihydrobiopterin and Biopterin in Human Urine, Serum and CSE -- Inhibition of Pterin Biosynthesis in the Adrenergic Neuroblastoma N1E115 by Tetrahydrobiopterin and Folate -- Penetration of Reduced Pterins into Rat Brain: Effect on Biogenic Amine Synthesis -- Neopterin Deficiency (GTP Cyclohydrolase I Deficiency), a New Variant of Hyperphenylalaninemia -- Folate Pathways in Cells from Fragile X Syndrome Patients and Carriers -- Report on Discussions -- Enzymology -- The Interaction of Substrates and Inhibitors with Dihydrofolate Reductase -- Catalytic Site of Dihydrofolate Reductase -- Structure, Function and Affinity Labelling Studies of Dihydrofolate Reductase -- Methylene Tetrahydrofoíate Reductase: Studies in a Human Mutant and Mammalian Liver -- Studies on Methylenetetrahydrofolate Reductase from Pig Liver: Catalytic Mechanism and Regulation by Adenosylmethionine -- Role of Methylenetetrahydrofolic Acid Reductase in Regulation of Folic Acid Metabolism and its Relation to the Methyl Trap Hypothesis -- The Mechanism of Action of the Transformylase Enzymes -- Folypolyglutamate Synthesis in Neurospora Crassa -- Report on Discussions -- Clinical Aspects: Cancer -- Folates and Cancer Chemotherapy -- Inability to Increase the Mobilisation of Liver Folates During Folate Deficiency Suggesting that this and Other Organs do not act as a Potential Folate Store for Marrow and Other Rapidly Proliferating Cells -- A High Molecular Weight Nonfunctional Immunoreactive Form of Dihydrofolate Reductase in L1210 Leukaemia Cells -- Further Characterization of the Pterdine Binding Variant of Alphas-Acid Glycoprotein, Accumulated in the Blood of Patients with Malignant Diseases -- Structure-Activity Relationships among 5-Substituted Lipophilic Diaminopyrimidine Antineoplastic Antifolates -- Attempts to Design Inhibitors of Dihydrofolate Reductase Using Interactive Computer Graphics with Real Time Energy Calculations -- Control of Methotrexate Polyglutamate Synthesis in Cultured Rat Hepatoma Cells -- Differential Effects of Methotrexate or Fluorodeoxyuridine upon Mitochondrial and Cellular Nucleotide Pools -- Report on Discussions -- Bioorganic Chemistry and Enzymology -- Chemical Mechanisms in the Action of Pteridine Coenzymes -- Irreversible Inactivation of Rat Liver Phenylalanine Hydroxylase by Reaction with (6S)-L-Erythro-Tetrahydrobiopterin -- p-Azidophenylalanine: A Potential Photoaffinity Probe for Rat-Liver Phenylalanine Hydroxylase -- Pyrimidine Models for the Cofactor of Phenylalanine Hydroxylase -- Activation of Molecular Oxygen by Tetrahydropterin Monooxygenases -- Mechanistic Studies on Phenylalanine Hydroxylase: Structural Determination of the Tetrahydropterin Intermediates -- Properties of Thymidylate Synthase from Streptococcus Faecium -- Cloning the Gene for Eukaryotic C1-THF Synthase -- Report on Discussions -- Biochemistry and Biology -- The Enzymatic Synthesis of the Drosopterins: Identification of a Pyrimidodiazepine as an Intermediate -- The Common Precursor of Sepiapterin and Drosopterin in Drosophila: Enzymatic and Chemical Synthesis -- The Common Precursor of Sepiapterin and Drosopterin in Drosophila: Enzymatic and Chemical Synthesis -- The Role of Pteridines in Regulation of Growth -- Evidence for a Folate Bound to Rat Hepatic Uroporphyrinogen III Cosynthase and its Role in the Biosynthesis of Heme -- Report on Discussions -- Presented Papers -- Aerobic Oxidation of 5,6,7,8-Tetrahydroneopterin -- The Conformations of 7,8 (6H)-Dihydropterin Substrates and the Activity of Dihydropterid...