Systems Biology

This book defines the field of systems biology, one of the newest and fastest developing fields in science today. It discusses the most effective experimental and computational strategies and highlights new and emerging applications. Cell biologists and other readers will discover many benefits for industry, such as the new network-based drug-target design validation. The authors also thoroughly explore testing.

Contenu

Systems Biology of Apoptosis.- Mathematical Modeling of the Wnt-Pathway.- Modeling Signaling Pathways - A Yeast Approach.- Mechanistic and Modular Approaches to Modeling and Inference of Cellular Regulatory Networks.- Scientific and Technical Challenges for Systems Biology.- Integration of Metabolic and Signaling Networks.- From Isolation to Integration, a Systems Biology Approach for Building the Silicon Cell.- What's Systems Biology: From Genes to Function and Back.- Systems Biology: Recent Developments and New Trends.- A Modular Systems Biology Analysis of the Cell Cycle Entrance into S Phase.- Metabolic Control Analysis.- Mesoscopic Kinetics and its Applications in Protein Synthesis.- E. coli Glycolysis.- Kinetic Modeling of the E. coli Metabolism.- No Music without Melody: How to Understand Biochemical Systems by Understanding Their Dynamics.- Systems Biology of the Yeast Cell Cycle Engine.- Quantification of in vivo Molecular Fluxes: A Key Methodology for Metabolic Systems Biology.-Modeling the E. coli cell: The Need for Computing, Cooperation, and Consortia.