It is more than 125 years since Louis Pasteur identified as the causative agent of "choléra des poules" the bacterium that now bears his name. Since that time, Pasteurella multocida has been recognized as the causative agent of a wide range of infections in a wide range of animal species as well as in humans. Indeed, the species name multocida could be literally translated as "multi-killer". The term pasteurellosis is now widely applied to describe infections of mammals and birds caused by P. multocida. It is therefore surprising that a detailed knowledge of the cellular and molecular basis for pathogenesis in pasteurellosis lags behind what has been elucidated for many other bacterial species. In particular, the molecular basis for host predilection remains completely unknown.

This volume brings together contributions from experts in the field of Pasteurella research. It covers areas such as comparative genomics, pathogenic mechanisms, bacterial proteomics, as well as a detailed description and analysis of Pasteurella multocida toxin and its interaction with host tissues, cells, immune system, and signalling pathways.

Résumé
This volume brings together contributions from experts in the field of Pasteurella research. Its covers areas such as comparative genomics, pathogenic mechanisms, bacterial proteomics, as well as a detailed description and analysis of PMT and its interaction with host tissues, cells, immune system, and signalling pathways.

Contenu

Preface.- Chapter 1 I.W. Wilkie, M. Harper, John D. Boyce, and B. Adler : Pasteurella multocida: Diseases and Pathogenesis.- Chapter 2 John D. Boyce, Torsten Seeman, Ben Adler, and Marina Harper: Pathogenomics of Pasteurella multocida.- Chapter 3 Marina Harper, John D. Boyce and Ben Adler: The Key Surface Components of Pasteurella multocida: Capsule and Lipopolysaccharide.- Chapter 4 Katharina Kubatzky: *Pasteurella multocida* and immune cells.- Chapter 5 Joachim H.C. Orth and Klaus Aktories: Molecular biology of Pasteurella multocida toxin.- Chapter 6 Brenda A. Wilson and Mengfei Ho: *Pasteurella multocida* toxin interaction with host cells: entry and cellular effects.- Chapter 7 Yasuhiko Horiguchi: Swine atrophic rhinitis caused by Pasteurella multocida toxin and Bordetella dermonecrotic toxin.- Chapter 8 Alistair Lax: The Pasteurella multocida toxin a new paradigm for the link between bacterial infection and cancer.- Subject index