Adverse Drug Effects

This practical guide to pharmacology is unusual in its approach. Instead of examining the normal effects of drugs this book looks at the adverse effects. With the advent of nurse prescribing it is essential that nurses are familiar with the common adverse effects, how to recognise them and how to deal with them. The book is divided into three sections. The first examines the pharmacology of drugs i.e. what the body does to drugs (pharmocokinetics), what the drugs do to the body (pharmocodynamics), and how adverse reactions can result from these two processes. Section two looks at putting the scientific knowledge into action through an examination of nurse administration and prescribing, drug development and the issue of patient compliance and empowerment. Section three consists of twelve case studies which describe various scenarios in which there have been adverse drug effects. Throughout the book concepts are explained using examples so that the nurse can relate the concept of adverse effect to the drugs she is familiar with.

Auteur

Jennifer Kelly is the author of Adverse Drug Effects: A Nursing Concern, published by Wiley.

Contenu
Preface ix

Introduction xi

PART 1 THE SCIENCE OF ADVERSE DRUG EFFECTS

Chapter 1 Pharmacokinetic effects absorption and distribution 3

Chapter 2 Pharmacokinetic effects metabolism and excretion 24

Chapter 3 Pharmacodynamics and receptors 37

Chapter 4 Pharmacodynamics, enzymes, ion channels and carriers 44

Chapter 5 Idiosyncratic effects and drug allergy 52

Chapter 6 Client groups 67

Chapter 7 Gastro-intestinal and hepatic effects 90

Chapter 8 Renal effects 111

Chapter 9 Cardiovascular and respiratory effects 128

Chapter 10 Neurological, sensory and endocrine effects 150

Chapter 11 Psychological effects 172

Chapter 12 Effects on the skin and musculoskeletal system 186

Chapter 13 Effects on the reproductive system and sexuality 202

Chapter 14 Drug resistance 215

PART 2 THE ART OF ADVERSE DRUG EFFECTS

Chapter 15 Nurse administration and prescribing 227

Chapter 16 Ethics of drug development and testing 241

Chapter 17 Compliance, patient education and empowerment 252

Chapter 18 Complementary therapy Debrae Ward-Walsh 268

PART 3 THE PRACTICE 12 CASE STUDIES

Chapter 19 Assessment issues 287

Chapter 20 Drug interactions 297

Chapter 21 Drug misuse 310

Chapter 22 Empowerment 323

Abbreviations and Glossary 336

Index 341