Many children are admitted to a pediatric intensive care unit (PICU) with serious infections or with a high chance of acquiring nosocomial infection once admitted. Any infection can be serious in an immunocompromised patient, while any delay in therapy may produce more severe infection in an immunocompetent patient. The increasing numbers of PICU admissions mean that knowledge of pediatric infections is vitally important for all involved to enable them to understand the reasons for admission, risks of nosocomial infection, infection control, modes of therapy, and outcomes.

Infectious Diseases in the Pediatric Intensive Care Unit has brought together all the current knowledge in the diagnosis and management of infectious disease on the PICU. Taking a practical and evidence-based approach, the editor and his renowned team of contributors provide a comprehensive clinical review of the subject in one easily accessible reference work from neonatal to adolescent and immunocompromised toimmunocompetent. It is therefore relevant to all clinicians working in intensive care, including pediatricians, PICU clinicians, emergency physicians, anesthetists, adult intensivists and nursing and care-based staff.

Auteur

Simon Nadel is on the advisory board of Intensive Care Medicine and is the Clinical Director of St Mary's Paediatric Intensive Care Unit, London, UK.

Résumé

Many children admitted to the pediatric intensive care unit (PICU) are admitted with serious infections. If they do not have serious infections prior to admission, there is also a high chance of them acquiring nosocomial infection once admitted. Many syndromes may lead to serious infection and the need for high dependency or intensive care. In addition, the numbers of children who are severely immunocompromised and surviving for extended periods are increasing. Any delay in therapy may produce more severe infection in an immunocompetent patient. As the influence of genetic factors in infectious disease becomes evident and new therapies and new modes of therapy have been introduced, there is the need to draw together these topics into one text. Infectious Diseases in the Pediatric Intensive Care Unit specifically examines infectious disease aspects of pediatric intensive care, from the reasons for admission, the risks of nosocomial infection, infection control, modes of therapy and outcomes.

Contenu
The Immunology of Neonates and Children and its Relation to Susceptibility to Infection.- Infections in the Critically Ill Neonate.- Fungal Infection in Critically Ill Children.- Toxin Mediated Diseases - Toxic Shock Syndrome.- Vaccines for the Prevention of Admission to the Paediatric Intensive Care Unit.- Pathophysiology of Pediatric Sepsis.- The Epidemiology of Severe Infections in Children.- Novel Challenges in Infection in the PICU Setting.- Host Genetic Susceptibility to Infection.- Nosocomial Infections in the Pediatric Intensive Care Unit.- Infections in the Immunocompromised Patient in PICU.- Infants and Children with HIV.- Life-Threatening Tropical Infections.- Cardiac Infections in the Pediatric Intensive Care Unit.- Paediatric Critical Care: Acute Central Nervous System Infection.- Respiratory Infection in Pediatric Intensive Care.- New Therapies for Sepsis.