Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products

Contenu

Cyclized Cembranoids of Natural Occurrence.- I. Introduction.- A. Nomenclature and Structural Representation.- II. Cyclized Cembranoids from Tobacco.- III. Cyclized Cembranoids from Insects.- A. Nasutitermitinae.- 1. Bulbitermes Species.- 2. Cortaritermes Species.- 3. Grallatotermes Species.- 4. Hospitalitermes Species.- 5. Longipeditermes Species.- 6. Nasutitermes Species.- 7. Subilitermes Species.- 8. Trinervitermes Species.- 9. Velocitermes Species.- IV. Cyclized Cembranoids from Marine Invertebrates.- A. Gorgonacea.- 1. Astrogorgia, Calicogorgia, Euniceila and Muricella Species.- 2. Briareum Species.- 3. Erythropodium Species.- 4. Junceella and Plexaureides Species.- B. Alcyonacea.- 1. Alcyonium Species.- 2. Cespitularia Species.- 3. Cladiella, Litophyton, Sclerophytum and Sinularia Species.- 4. Gersemia Species.- 5. Minabea Species.- 6. Sarcophyton Species.- C. Stolonifera.- D. Pennatulacea.- 1. Cavernulina, Pteroides, Ptilosarcus, Renilla, Scytalium and Stylatula Species.- 2. Veretillum Species.- Addendum.- Acknowledgements.- References.- Chemical Synthesis of Heparin Fragments and Analogues..- 1. Introduction.- 1.1 Heparin.- 1.2 Heparin Fragments.- 2. Synthesis of the Antithrombin Binding Site.- 2.1 Strategy.- 2.2 Preparation of D-Glucuronic Acid Derivatives.- 2.3 Preparation of L-Iduronic Acid Derivatives.- 2.4 Synthesis of the Fully Protected Pentasaccharides.- 2.5 Synthesis of Building Blocks from Natural Disaccharides.- 2.5.1 Synthesis from Cellobiose.- 2.5.2 Synthesis from Maltose.- 2.6 Deprotection and Functionalisation.- 2.7 Recent Results in the Synthesis of the Antithrombin Binding Site.- 2.7.1 Synthesis of the ?-Methyl Glycoside of the Antithrombin Binding Site.- 2.7.2 Synthesis of the N-Acetylated Antithrombin Binding Sequence.- 3. Synthesis and Biological Properties of Analogues of the Antithrombin Binding Site.- 3.1 Analogues lacking N, O-Sulphate Groups at Defined Positions.- 3.2 Analogues with Modifications of the Carboxylate Groups at Defined Positions.- 3.3 A Potent Analogue with Extra 3-O-Sulphate Group at Unit H.- 3.4 Analogues of the Extra Sulphated, Potent Analogue (81).- 3.5 Analogues Containing "Opened" Uronic Acid Moieties.- 3.6 Analogues with Various Modifications.- 3.7 Alkylated Analogues of Heparin Pentasaccharides.- 4. Conformational Properties.- 5. Interaction of Heparin Pentasaccharide Fragments with Antithrombin III.- Acknowledgements.- References.- Author Index.- General Index Vol. 21-60.