Factors Affecting Neurodevelopment

Factors Affecting Neurodevelopment: Genetics, Neurology, Behavior, and Diet is a comprehensive reference on the genetic and behavioral features associated with proper and abnormal development. The book discusses the mechanisms underlying neurological development and provides readers with a detailed introduction to the neural connections and complexities in biological circuitries, as well as the physiological, behavioral, molecular, and cellular features of neurodevelopment. In addition, the book examines in vitro and in vivo modeling of development with stem cells and model systems.

• Provides the most comprehensive coverage of a broad range of topics relating to the neuroscience of development
• Features sections on the genetics of developmental conditions and accompanying behavior
• Contains an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding in each chapter
• Focuses on neurodevelopmental disorders and environmental factors that influence neural development
• Includes more than 500 illustrations and tables

Contenu

I. Genetics, Molecular and Celluar Biology 1. Hereditary motor neuropathies 2. Dopamine transporter (DAT1) polymorphism and development 3. Genome wide association studies (GWAS) and neurodevelopment: Autism spectrum disorder 4. SNPs and cerebral palsy 5. Epigenetic regulation of cortical neurogenesis 6. Functions and dynamics of axonal mitochondria 7. Linking apoptosis and caspases in fetal neural tube defects 8. Brain oxidative stress in Down syndrome 9. Linking Adhesion GPCRs to Glial Cell Development and Function 10. Immunoglobulin cell adhesion molecule superfamily and neurodevelopment 11. Brain-derived neurotrophic factor (BDNF) and neurogenesis 12. slc7a5 and neural development 13. Linking SOX3, SRY and disorders of neurodevelopment 14. Neuronal Src-homology-2 (SH2)B adaptor protein-1 (Sh2b1) and brain growth 15. Effects of extrinsic factors and intracellular signalling and transcription factors regulating the development and cell fate of spinal cord ependymal cells 16. Signaling molecules controlling oligodendrocyte development and brain myelination

II. Neurological and Imaging Features 17. Fetal brain structures: imaging oriented 18. Four-dimensional (4D) ultrasonography: Methods, uses and fetal neuroscience 19. Linking histology and neurological development of the fetal and infant brain 20. Development of Corticospinal tract axons: from embryonic stage to adulthood 21. Vascular endothelial growth factor (VEGF) and neurodevelopment 22. Brain-wide connectivity architecture: developmental aspects 23. Development and pathology of the germinal matrix 24. Development of the GABAergic network in the mouse spinal cord 25. Postnatal development, electrophysiology and sensory sural nerves 26. Neuroscience of the developing axonal strata in the human fetal brain 27. Neuroactive steroids and neurodevelopment 28. Voltage and ligand-gated ion channels appearance and function in neurodevelopment 29. Features of brain development over 13 years in preterms 30. The medial pulvinar in neurodevelopment 31. Cortical sulci in the human fetal brain and development 32. The prenatal development of the human cerebellum 33. Developing cerebello-cerebral connectivity in health and disease: a focus on epilepsy 34. Prenatal exposure to progestins: impact on neurodevelopment of the child

III. Physiological Aspects 35. Brain lesion characteristics in relation to upper limb function in children with unilateral cerebral palsy 36. Maternal exercise and brain development 37. Pyramidal neurons: physiology, Pathophysiology and postnatal development 38. Working memory: physiology and neurodevelopment 39. EEG development in resting states 40. Availability and metabolism of thyroid hormones in the developing brain

IV. Behavior and Psychopathological Aspects 41. Psychosocial issues and quality of life following childhood stroke 42. Neuropsychological function following childhood stroke 43. Youths with autism and working memory 44. Linking the mesial temporal lobe, 3D probabilistic maps and development 45. Cognitive aspects of Down Syndrome 46. Adolescent cannabis use and neurocognitive development 47. The Role of Social Anxiety in Autism and the Broader Autism Phenotype: Evidence from Childhood through Adulthood 48. Impact of touch on bonding and neurodevelopment 49. Neurobehaviour and catch up growth

V. Diet and Nutrition 50. Caloric restriction and the developing brain 51. High-fat diet, tryptophan hydroxylase-2 mRNA expression and neurodevelopment 52. Bone mineral density and nutritional status in children with cerebral palsy 53. Epigallocatechin-3-gallate: Linking the neurogenesis, hippocampus and Down syndrome 54. Folic acid-to prevent spina bifida and anencephaly