Experimental and Clinical Progress in Cancer Chemotherapy

As in CANCER CHEMOTHERAPY 1, this volume brings to the reader highlights in three different areas of cancer therapeutics: new concepts and models; drug classes; and clinical settings. Topics were chosen because of their timeliness or probable current impact in cancer treatment. Authors were selected on the basis of their ability to provide a critical overview of specific subjects and their involvement in original work. I shall review the aims of this second volume, and then elaborate on the scope of its con­ tents. The principal aim of the volumes on cancer chemotherapy in the' Cancer Treatment and Research' series, as stated in the preface to the first volume, is to assemble in a concentrated form selected ingredients of chemothera­ peutic progress. These ingredients are to include concepts in therapeutic strategy, pre-clinical studies, development of major classes of compounds, identificatlon of new directions and of landmarks of clinical progress. Thus we do not foresee overlap with series which provide an yearly update of chemotherapy in an encyclopedic manner, or reviews of cancer chemother­ apy. Unlike those publications, our volumes are not intended to seek a place in shelves as a reference manual. It is this Editor's hope that persons repre­ senting various biomedical disciplines will seek the' Cancer Treatment and Research' chemotherapy volumes to survey advances in the field at regular intervals.

Contenu

1. Cytotoxic Base Propenals from DNA.- 2. Lipid Macromolecules as Chemotherapeutic Target.- 3. Metabolism-Dependent Toxicities of Cyclophosphamide and Protection by N-Acetylcysteine and other Thiols.- 4. Cell Surface Membranes as a Chemotherapeutic Target.- 5. Development of Fluoropyrimidines: Japanese Experience.- 6. DNA Modification by the Nitrosoureas: Chemical Nature and Cellular Repair.- 7. Thymidylate Synthetase Inhibitors: Experimental and Clinical Aspects.- 8. Autologous Bone Marrow Transplantation (ABMT) and High-Dose Chemotherapy in Small Cell Lung Cancer.- 9. Chemotherapy in Osteosarcoma: Advances and Controversies.- 10 Current Issues in the Evaluation and Treatment of Epithelial Carcinoma of the Ovary.