Molecules and Medicine

Molecules and Medicine provides, for the first time ever, a completely integrated look at chemistry, biology, drug discovery, and medicine. It delves into the discovery, application, and mode of action of more than one hundred of the most significant molecules in use in modern medicine. Opening sections of the book provide a unique, clear, and concise introduction, which enables readers to understand chemical formulas.

Auteur
E. J. Corey has been a Professor at Harvard University since 1959. He was educated at The Massachusetts Institute of Technology (1945-1950) and served as a faculty member at the University of Illinois from1951 to 1959. He is the 1990 Nobel Laureate in Chemistry, and the recipient of over seventy international awards and honorary degrees, including the U.S. National Medal of Science, the Japan Prize in Science, and the Priestley Medal of the American Chemical Society. He is amember of the U.S. National Academy of Sciences and the U.S. National Institute of Medicine. Professor Corey is the author of more than 1,000 publications and is one of the most cited authors in science. Barbara Czakó completed undergraduate studies at the University of Debrecen, Hungary, where she worked with Dr. Sándor Berényi. She obtained a Master of Science degree at the University of Missouri-Columbia with Professor Shon R. Pulley. Dr. Czakó received her Ph.D. degree (2006) in synthetic organic chemistry under the guidance of Professor Gary A. Molander at the University of Pennsylvania. Currently she is a postdoctoral fellow with Professor E.J. Corey at Harvard University. In 2005 she published with László Kürti the textbook Strategic Applications of Named Reactions in Organic Synthesis.

László Kürti was born and raised in Hungary. He received his diploma from the University of Debrecen, Hungary, where he conducted research in the laboratory of Professor Sándor Antus. Subsequently he received his Master of Science degree at the University of Missouri-Columbia working with Professor Michael Harmata, and his Ph.D. degree (2006) in synthetic organic chemistry under the supervision of Professor Amos B. Smith III (the University of Pennsylvania). Currently he is a Damon Runyon Cancer Fellow in the group of Professor E.J. Corey at Harvard University. In 2005 he published with Barbara Czakó the textbook Strategic Applications of Named Reactions in Organic Synthesis.

Texte du rabat
Molecules And Medicine This book is appropriate for a broad readership, starting with curious and thoughtful college undergraduates and reaching beyond to professors and researchers in the life sciences, chemistry, and medicine. This book provides, for the first time ever, a completely integrated look at chemistry, biology, drug discovery, and medicine.

Molecules and Medicine delves into the discovery, application, and mode of action of more than one hundred of the most significant molecules now in use in modern medicine. Molecule structures and shapes are shown for all of these medicines. The opening sections of the book provide a unique, clear, and concise introduction which enables the reader to understand chemical formulas.

Résumé
Molecules and Medicine provides, for the first time ever, a completely integrated look at chemistry, biology, drug discovery, and medicine. It delves into the discovery, application, and mode of action of more than one hundred of the most significant molecules in use in modern medicine. Opening sections of the book provide a unique, clear, and concise introduction, which enables readers to understand chemical formulas.

Contenu

Part I.

Introduction 2

Understanding Structural Diagrams of Organic Molecules 4

Some Common Molecules 23

Proteins and Three-Dimensional Protein Structure 26

Some of the Protein Structures That Appear in This Book 32

Part II. Inflammatory, Cardiovascular and Metabolic Diseases

Anti-Inflammatory Agents

Acetylsalicylic acid (AspirinTM) 38

Naproxen (AleveTM) 39

How Do Anti-Inflammatory Drugs Work? 40

Other Eicosanoids in Inflammation 41

An Overview of Inflammation 42

Celecoxib (CelebrexTM) 43

Prednisone (DeltasoneTM) 44

Methotrexate (TrexallTM) 46

Allopurinol (ZyloprimTM) 47

Antiasthmatic and Antiallergic Agents

Salmeterol (SereventTM) 50

Fluticasone Propionate (FloventTM) 51

Montelukast Sodium (SingulairTM) 52

Tiotropium Bromide (SpirivaTM) 53

Loratadine (ClaritinTM) 54

Type 2 Diabetes

An Overview of Metabolic Syndrome 56

Antidiabetic and Cholesterol-Lowering Agents

Metformin (GlucophageTM) 60

Glipizide (GlucotrolTM) 61

Pioglitazone (ActosTM) 62

Sitagliptin (JanuviaTM) 63

Atorvastatin (LipitorTM) 64

Ezetimibe (ZetiaTM) 65

Cardiovascular Agents

Atenolol (TenorminTM) 68

Enalapril (VasotecTM) 69

Candesartan Cilexetil (AtacandTM) 70

Aliskiren (TekturnaTM) 71

Amlodipine (NorvascTM) 72

Nitroglycerin 73

Clopidogrel Bisulfate (PlavixTM) 74

Digoxin (LanoxinTM) 75

Receptors and Signaling

Information Flow into the Cell by Chemical Signaling 78

References for Part II 80

Part III. Reproductive Medicine

Oral Contraceptives 90

Testosterone 91

Mifepristone (MifeprexTM) 92

Oxytocin (OxytocinTM) 93

Sildenafil (ViagraTM) 94

Osteoporosis

Some Aspects of Osteoporosis 96

Alendronate (FosamaxTM) 97

Calcitriol (RocaltrolTM) 98

Raloxifene (EvistaTM) 99

Teriparatide (ForteoTM) 100

Glaucoma and Antiulcer Agents

Latanoprost (XalatanTM) 102

Ranitidine (ZantacTM) 103

Omeprazole (PrilosecTM) 104

References for Part III 105

Part IV. Autoimmune Disease and Organ Transplant

A Brief Survey of the Immune System 112

Immunosuppressive Agents

Azathioprine (ImuranTM) 122

Mycophenolate Mofetil (CeIlCeptTM) 123

Cyclosporin (NeoralTM) 124

Tacrolimus (PrografTM) 125

FTY720 (Fingolimod) 126

Infectious Diseases

Antibiotics

Amoxicillin (AmoxilTM) 130

Cefaclor (CeclorTM) 132

Doxycycline (VibramycinTM) 133

Azithromycin (ZithromaxTM) 134

Ciprofloxacin (CiproTM) 135 Trimethoprim ...