Pituitary apoplexy is a rare and life-threatening complication that occurs in 0.6-10.5% of all patients with pituitary adenomas. Unfortunately, pituitary apoplexy is often misdiagnosed before surgery. Furthermore, in spite of all the advances in imaging techniques and therapeutic methods, its optimal management is still controversial owing to the limited individual experience and the very variable clinical course of the condition, which ranges from asymptomatic to critical illness with visual loss and subarachnoid hemorrhage. The management of visual dysfunction in particular remains a subject of debate.

This book provides an in-depth review of knowledge of the management of pituitary apoplexy, with an emphasis on clinical and neuroradiological findings and treatment modalities, medical and surgical. In addition, it supplies clinicians and investigators with detailed information on current evidence and considers future areas of investigation and innovative therapeutic philosophies. Both the editors and the authors are leading international authorities in the field.

Auteur

Mehmet Turgut, MD, PhD, is an Assistant Professor in the Department of Neurosurgery at Adnan Menderes University School of Medicine, Aydn, Turkey. He graduated in Medicine at the Ege University School of Medicine, zmir, Turkey and subsequently obtained his Specialization in Neurosurgery from Hacettepe University School of Medicine. In 2004 he was awarded his PhD by the Ege University Health Sciences Institute, zmir, Turkey. Dr. Turgut has authored more than 250 publications, many of them in peer-reviewed journals and 3 books. He is a member of the editorial boards of various journals, including Journal of Spine, Central European Neurosurgery, Journal of Brachial Plexus and Peripheral Nerve Injury, and Journal of Spine and Neurosurgery.

Ashok Kumar Mahapatra, BSc, MB BS, M.S. (Surgery), M.Ch. (Neurosurgery), is Professor of Neurosurgery at the Department of Neurosurgery, AIIMS, New Delhi, India and also Honorary Visiting Professor to CBMR Lucknow. He is a past Director of the Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow. Currently he is working as Director, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India since August 2012. Dr. Mahapatra is the recipient of numerous awards, and in 2004 he became a Fellow of the National Academy of Sciences. He has also held many important administrative appointments. Dr. Mahapatra has conducted research in various areas and is the author or editor of 13 books and more than 485 journal papers and 115 book chapters.

Michael Peter Powell, MA (Oxon), MB BS (Lond), FRCS (Eng), FRCP (Lond), is a Consultant Neurosurgeon at the National Hospital for Neurology and Neurosurgery, London and Civilian Neurosurgeon to the Royal Air Force. Dr. Powell is an examiner for the Intercollegiate Board of Colleges of Surgeons in Neurosurgery and from 2008 to 2010 was Chairman of the Neurosurgery Specialty Advisory Committee of the Joint Committee on Surgical Training, Royal Colleges of Surgeons. Dr. Powell has held many further appointments as an honorary consultant neurosurgeon. He is the author of more than 60 articles in peer-reviewed journals and of the book The Management of Pituitary Tumours, published in 2004.

Natarajan Muthukumar, MB BS, M.Ch. (Neurosurgery), is Professor and Head of the Department of Neurosurgery at Madurai Medical College, Madurai, India. Dr. Muthukumar is Associate Editor of Neurology India, the official journal of the Neurological Society of India, and a referee for a number of other leading journals. He has been the author of 76 publications, most of them in peer-reviewed journals. His research interests include in particular congenital malformations of the nervous system, spinal surgery, and neurotrauma.

Contenu
Introduction: Definition, History, Frequency, Histopathology and Pathophysiology of Pituitary Apoplexy. Overview: Conservative versus Surgical Decompression for Pituitary Apoplexy. Tumours Types which Show Apoplexy: Predisposing factors for Pituitary Apoplexy.- Non-functioning tumour apoplexy.- Apoplexy in previously known tumours.- Post-operative Pituitary Apoplexy. Clinical Features: Clinical features of Pituitary Apoplexy.- Subarachnoid hemorrhage with Pituitary Adenoma.- Cerebral ischaemia in Pituitary Apoplexy. Visual and Endocrine Assessment: Visual acuity, eye movements and visual fields.- Visual outcome following Pituitary Apoplexy.- Preoperative endocrine function and fluid electrolyte balance.- Endocrinopathies and other biochemical abnormalities in Pituitary Apoplexy. Mimicking Conditions: Carotid artery aneurysm.- Hypothalamic lymphoma.- Rathke's cleft cysts mimicking Pituitary Apoplexy. Management: Conservative management of Pituitary Apoplexy.- Surgical decompression for Pituitary Apoplexy.- Timing of surgery and outcome in Pituitary Apoplexy. Complications: Subarachnoid hemorrhage after transsphenoidal surgery.