Molecular Biology

The last quarter of the 20th century saw major scientific revolutions in genetics and computer technology. The second edition of Molecular Biology, winner of a 2013 Texty Award from the Text and Academic Authors Association, reflects this massive surge in our understanding of the molecular foundations of genetics. In order to understand where these technological advances are heading, there needs to be a basic understanding of how living organisms function at a molecular level. This volume effectively introduces basic concepts followed by more specific applications as the text evolves. With the addition of Cell Press articles, the content is tied to current topics in the scientific community.

NEW: 'Focus On Relevant Research' sections integrate primary literature from Cell Press and focus on helping the student learn how to read and understand research to prepare them for the scientific world.
NEW: Academic Cell Study Guide features all articles from the text with concurrent case studies to help students build foundations in the content while allowing them to make the appropriate connections to the text.
NEW: Animations provided include topics in protein purification, transcription, splicing reactions, cell division and DNA replication and SDS-PAGE
Updated chapters on Genomics and Systems Biology, Proteomics, Bacterial Genetics and Molecular Evolution and RNA
Updated ancillary package includes flashcards, online self quizzing, references with links to outside content and PowerPoint slides with images.
Fully revised art program

Molecular Biology, Second Edition, examines the basic concepts of molecular biology while incorporating primary literature from today's leading researchers. This updated edition includes Focuses on Relevant Research sections that integrate primary literature from Cell Press and focus on helping the student learn how to read and understand research to prepare them for the scientific world.

The new Academic Cell Study Guide features all the articles from the text with concurrent case studies to help students build foundations in the content while allowing them to make the appropriate connections to the text. Animations provided deal with topics such as protein purification, transcription, splicing reactions, cell division and DNA replication and SDS-PAGE. The text also includes updated chapters on Genomics and Systems Biology, Proteomics, Bacterial Genetics and Molecular Evolution and RNA. An updated ancillary package includes flashcards, online self quizzing, references with links to outside content and PowerPoint slides with images.

This text is designed for undergraduate students taking a course in Molecular Biology and upper-level students studying Cell Biology, Microbiology, Genetics, Biology, Pharmacology, Biotechnology, Biochemistry, and Agriculture.

• NEW: "Focus On Relevant Research" sections integrate primary literature from Cell Press and focus on helping the student learn how to read and understand research to prepare them for the scientific world.
• NEW: Academic Cell Study Guide features all articles from the text with concurrent case studies to help students build foundations in the content while allowing them to make the appropriate connections to the text.
• NEW: Animations provided include topics in protein purification, transcription, splicing reactions, cell division and DNA replication and SDS-PAGE
• Updated chapters on Genomics and Systems Biology, Proteomics, Bacterial Genetics and Molecular Evolution and RNA
• Updated ancillary package includes flashcards, online self quizzing, references with links to outside content and PowerPoint slides with images.
• Fully revised art program

Auteur

David P. Clark did his graduate work on bacterial antibiotic resistance to earn his Ph.D. from Bristol University, in the West of England. During this time, he visited the British Government's biological warfare facility at Porton Down and was privileged to walk inside the (disused) Black Death fermenter. He later crossed the Atlantic to work as a postdoctoral researcher at Yale University and then the University of Illinois. David Clark recently retired from teaching Molecular Biology and Bacterial Physiology at Southern Illinois University which he joined in 1981. His research into the Regulation of Alcohol Fermentation in E. coli was funded by the U.S. Department of Energy, from 1982 till 2007. From 1984-1991 he was also involved in a project to use genetically altered bacteria to remove contaminating sulfur from coal, jointly funded by the US Department of Energy and the Illinois Coal Development Board. In 1991 he received a Royal Society Guest Research Fellowship to work at Sheffield University, England while on sabbatical leave. He has supervised 11 master's and 7 PhD students and published approximately 70 articles in scientific journals. He has written or co-authored several textbooks, starting with Molecular Biology Made Simple and Fun (with Lonnie Russell; (Cache River Press, First edition, 1997) which is now in its fourth edition. Other books are Molecular Biology and Biotechnology (both published by Elsevier) He recently wrote a popular science book, Germs, Genes, & Civilization: How Epidemics Shaped Who We Are Today (2010, Financial Times Press/Pearson). David is unmarried, but his life is supervised by two cats, Little George and Mr Ralph.

Contenu

Unit 1: Basic Chemical and Biological Principles

Ch1 Cells and Organisms

Ch2 Basic Genetics

Ch3 DNA, RNA, and Protein

Ch4 Genes, Genomes, and DNA

Ch5 Manipulation of Nucleic Acids

Unit 2: The Genome

Ch6 Polymerase Chain Reaction

Ch7 Cloning Genes for Analysis

Ch8 DNA Sequencing

Ch9 Genomics & Systems Biology

Unit 3: The Central Dogma of Molecular Biology

Ch10 Cell Division and DNA Replication

Ch11 Transcription of Genes

Ch12 Processing of RNA

Ch13 Protein Synthesis

Ch14 Protein Structure & Function

Ch15 Proteomics: Global Analysis of Proteins

Unit 4: Regulating Gene Expression

Ch16 Regulation of Transcription in Prokaryotes

Ch17 Regulation of Transcription in Eukaryotes

Ch18 Regulation at RNA Level

Ch19 Analysis of Gene Expression (Transcriptome)

Unit 5: Subcellular Life Forms

Ch20 Plasmids

Ch21 Viruses

Ch22 Mobile DNA

Unit 6: Changing the DNA Blueprint

Ch23 Mutations and Repair

Ch24 Recombination

Ch25 Bacterial Genetics

Ch26 Molecular Evolution