Concepts, Clinical Developments, and Therapeutic Advances in Cancer Chemotherapy

Contenu

I. Concepts.- 1. DNA filter elution methods in anticancer drug development.- 2. Intraperitoneal chomotherapy: Principles and results of clinical trials.- II. New Drugs and New Clinical Investigation.- 3. Metabolites of tiazofurin as mediators of its biochemicaland pharmacologic effects..- 4. Extragonadal and central nervous system germ cell tumors:A review of diagnostic and therapeutic strategies.- 5. Role of preclinical pharmacology in phase I clinical trials:Considerations of schedule-dependence.- 6. Interferon: Current concepts of mechanisms of action.- 7. Acivicin: A new antimetabolite.- III. Specific Therapeutic Landmarks.- 8. Chemotherapy for malignant intracranial tumors.- 9. New antiviral compounds and impact in management of neoplastic disease and AIDS.- 10. The clinical horizon of deoxycoformycin.