Drug Delivery Applications of Noninvasive Imaging

Cost-effective strategies for designing novel drug delivery
systems that target a broad range of disease conditions

In vivo imaging has become an important tool for the
development of new drug delivery systems, shedding new light on the
pharmacokinetics, biodistribution, bioavailability, local
concentration, and clearance of drug substances for the treatment
of human disease, most notably cancer. Written by a team of
international experts, this book examines the use of quantitative
imaging techniques in designing and evaluating novel drug delivery
systems and applications.

Drug Delivery Applications of Noninvasive Imaging offers
a full arsenal of tested and proven methods, practices and
guidance, enabling readers to overcome the many challenges in
creating successful new drug delivery systems. The book begins with
an introduction to molecular imaging. Next, it covers:

• In vivo imaging techniques and quantitative
  analysis

• Imaging drugs and drug carriers at the site of action,
  including low-molecular weight radiopharmaceuticals, peptides and
  proteins, siRNA, cells, and nanoparticles

• Applications of imaging techniques in administration routes
  other than intravenous injection, such as pulmonary and oral
  delivery

• Translational research leading to clinical applications

• Imaging drug delivery in large animal models

• Clinical applications of imaging techniques to guide drug
  development and drug delivery

Chapters are based on a thorough review of the current
literature as well as the authors' firsthand experience working
with imaging techniques for the development of novel drug delivery
systems.

Presenting state-of-the-technology applications of imaging in
preclinical and clinical evaluation of drug delivery systems,
Drug Delivery Applications of Noninvasive Imaging offers
cost-effective strategies to pharmaceutical researchers and
students for developing drug delivery systems that accurately
target a broad range of disease conditions.

Auteur

CHUN LI, PhD, is Professor and Ad Interim Chief,
Chemistry Section, in the Department of Cancer Systems Imaging at
the University of Texas MD Anderson Cancer Center. He is Associate
Editor of Cancer Nanotechnology and a member of the
editorial boards of American Journal of Nuclear Medicine and
Molecular Imaging and Quantitative Imaging in Medicine and
Surgery. Dr. Li has more than 120 peer-reviewed publications
and holds twenty-eight patents.

MEI TIAN, MD, is Vice President of Hangzhou Binjiang
Hospital and Professor of Diagnostic Imaging and Nuclear Medicine
at The Second Hospital, Zhejiang University School of Medicine. Dr.
Tian is also an editorial consultant for The Lancet. She is
a member of the editorial boards of Journal of Nuclear Medicine,
European Journal of Nuclear Medicine and Molecular Imaging, Nuclear
Medicine Communications, and Oncology.

Résumé

Cost-effective strategies for designing novel drug delivery systems that target a broad range of disease conditions

In vivo imaging has become an important tool for the development of new drug delivery systems, shedding new light on the pharmacokinetics, biodistribution, bioavailability, local concentration, and clearance of drug substances for the treatment of human disease, most notably cancer. Written by a team of international experts, this book examines the use of quantitative imaging techniques in designing and evaluating novel drug delivery systems and applications.

Drug Delivery Applications of Noninvasive Imaging offers a full arsenal of tested and proven methods, practices and guidance, enabling readers to overcome the many challenges in creating successful new drug delivery systems. The book begins with an introduction to molecular imaging. Next, it covers:

• In vivo imaging techniques and quantitative analysis
• Imaging drugs and drug carriers at the site of action, including low-molecular weight radiopharmaceuticals, peptides and proteins, siRNA, cells, and nanoparticles
• Applications of imaging techniques in administration routes other than intravenous injection, such as pulmonary and oral delivery
• Translational research leading to clinical applications
• Imaging drug delivery in large animal models
• Clinical applications of imaging techniques to guide drug development and drug delivery
  Chapters are based on a thorough review of the current literature as well as the authors' firsthand experience working with imaging techniques for the development of novel drug delivery systems.

Presenting state-of-the-technology applications of imaging in preclinical and clinical evaluation of drug delivery systems, Drug Delivery Applications of Noninvasive Imaging offers cost-effective strategies to pharmaceutical researchers and students for developing drug delivery systems that accurately target a broad range of disease conditions.

Contenu

Preface ix

contributors xi

1 Introduction to Molecular Imaging 1

Vikas Kundra

2 PET/SPECT: Instrumentation and Imaging Techniques 12

Yuan-Chuan Tai

3 Photoacoustic Tomography and Its Applications in Drug Delivery
and Photothermal Therapy 45

Liang Song and Lihong V. Wang

4 Raman Microspectral Imaging for Label-Free Detection of
Nanoparticle-Mediated Cellular and Subcellular Drug Delivery
70

Tatyana Chernenko, Lara Milane, Christian Matthäus, Max
Diem, and Mansoor Amiji

5 A natomical and Functional MRI91

Edward F. Jackson

6 Quantitative Imaging in Drug Delivery 125

Kooresh I. Shoghi

7 PET Imaging of the Pharmacokinetics of Small Molecular-Weight
Drugs 147

Stephen M. Moerlein and Zhude Tu

8 Imaging Peptides, Proteins, and Antibody Delivery 192

Frederik L. Giesel and Clemens Kratochwil

9 In Vivo Imaging and Delivery of siRNA199

Zdravka Medarova and Anna Moore

10 Imaging Cell Therapy 223

Yajie Liang and Jeff W. M. Bulte

11 Radiolabeled Liposomes as Drug Delivery Nanotheranostics
252

William T. Phillips, Ande Bao, Keitaro Sou, Shihong Li, and Beth
Goins

12 Polymeric Micelles as Imaging Agents and Drug Delivery
Systems 268

Jun Zhao and Chun Li

13 Perfluorocarbon Nanoparticles: Translating Bench
Opportunities to the Clinic 296

G. M. Lanza, P. M. Winter, S. D. Caruthers, A. H. Schmieder, and
S. A. Wickline

14 Cancer Theranostics with Hollow Gold Nanospheres 308

Wei Lu and Chun Li

15 Imaging Pulmonary Drug Delivery 333

Stephen P. Newman

16 In Vivo Imaging for Validation of Oral Dose Performance
367

Fiona J. McInnes and Howard N. E. Stevens

17 Role of Large Animal Models in Translational Studies of
Imaging and Targeted Drug Delivery 389

Rajesh K. Uthamanthil and Mei Tian

18 Imaging Transcatheter Delivery to Liver Tumors 412

Adil Al-Nahhas, Meeran Naji, and Imene Zerizer

19 Direct Visualization of Therapeutic Radionuclide Distribution
Using Nuclear Medicine Imaging: I-131 in Metastatic Thyroid
Carcinoma 426

Ho Young Lee, June-Key Chung, So Won Oh, Jong Jin Lee, Keon Wook
Kang, Do Joon Park, Bo Youn Cho, and Myung Chul Lee

20 Imaging Drug Delivery to the CNS Using Translational Positron
Emission Tomography Studies 432

Chi-Ming Lee, Katarina Varnäs, and Lars Farde

Index 449