Bone Metastasis and Molecular Mechanisms

Patients with advanced breast or prostate cancers usually develop bone metastases. The principal complications resulting from metastatic bone disease are pain, spinal cord compression, pathologic fractures and bone marrow suppression. Improving the management of bone metastases is crucial to quality of life for patients with breast and prostate cancer.

Advances in understanding of the molecular mechanisms underlying the pathophysiology of bone metastasis are driving the development of new therapeutic strategies.

Contenu

List of Contributors Preface; Gurmit Singh 1 Models of Breast Cancer Metastasis to Bone: Characterization of a Clinically Relevant Model; Belinda S. Parker, Bederich L. Eckhardt and Robin L. Anderson 2 Quantitation of Bone Metastasis in Experimental Systems; Julie A. Sharp and Erik W. Thompson 3 Comparative Morphometric Study on Bone Remodeling in Human Specimens and in Experimental Models of Metastatic Bone Disease; Snezana Vukmirovic-Popovic, Eric Seidlitz, F. William Orr and Gurmit Singh 4 Clinical Modalities for the Diagnosis, Characterization and Detection of Bone Metastases; Michael H. Weber, Jonathan C. Sharp, Thomas H. Hassard, Martin Reed, James A. Thliveris and F. William Orr 5 Metastasis in the Bone Marrow Microenviroment; Paolo Bianco, Mara Riminucci and Pamela Gehron Robey 6 The Role of Tumor-Associated Macrophages in Metastasis-Associated Osteolysis; Nicholas. A. Athanasou 7 The Malignant Hierarchy in Multiple Myeloma: Relationships between Malignant Cells and Bone Disease; Linda M. Pilarski, Tony Reiman, Patrick M. Pilarski, F. William Orr and Andrew R. Belch 8 Angiogenesis and Lymphangiogenesis in Metastatic Bone Disease: A Matter of Networking; Gabri Van Der Pluijm, and Jeroen Buijs 9 Prostate Cancer: Models for Developing Novel Therapeutic Approaches; Shafaat A. Rabbani, Nicholas Shukeir and Andrew P. Mazar 10 Potential Therapeutic Targets for Bone Metastasis; Sadmeet Singh and Gurmit Singh 11 OPG, RANK and RANKL in Bone Metastasis and Cancer-Associated Osteolysis; Paul L Kostnuik 12 Role of Matrix Metalloproteinases in Bone Metastasis from Human Breast and Prostate Cancer; Wilhelmina C.M. Duivendoorden and Gurmit Singh 13 The Role of Bisphosphonates in Bone Metastasis; Mary Mackenzie and Pierre Major Index