In this book, the authors discuss the biophysical characteristics of Dendritic cells (DCs) at various differentiation stages and in tumor microenvironments in detail. A type of Chinese traditional herb, which can improve the biophysical and microrheological properties of DCs, is also introduced. DCs are potent and specialized antigen-presenting cells that play a crucial role in initiating and amplifying both the innate and adaptive immune responses. The biophysical and microrheological characteristics of DCs are important for their motility and normal immune function. In tumor microenvironments, the motility and immune functions of DCs are impaired, but the mechanisms are largely unknown. This book offers researchers a comprehensive and deep insight into the biophysical characteristics of DCs and may also help to improve the efficiency of anti-tumor therapy based on DCs.

Summarizing the cutting-edge studies on biophysical properties of DCs Comprehensively overviewing the biophysical properties of DCs at different differentiation stage and tumor microenvironment Exploring the immune escape mechanisms of tumor cells Provide a potential clinical treatment for tumors based on DCs Includes supplementary material: sn.pub/extras

Auteur
Zhu Zeng is a professor of the Department of Biotechnology, and the vice president of the School of Basic Medical Sciences, Guiyang Medical College. He was awarded as the distinguished young science and technology scholars of Guizhou Province in 2011. Since 2000, his main research interests focused on biophysical characteristics of dendritic cells. Xiaofeng Xu is a doctor in the department of Laboratory Medicine, Beijing Tongren Hospital, Capital Medical University. Her research interests focused on biophysical characteristics of dendritic cells. Dan Chen is a lecturer of the Department of Pharmacology, School of Basic Medical Sciences, Tianjin Medical University. Her main research interests focused on the effects of traditional Chinese medicine on tumor biological behaviors.

Contenu
Summary.- Introduction.- The measurement protocols of cell biophysical characteristics.- Biophysical characteristics of dendritic cells at different differentiation stages.- Biophysical characteristics of dendritic cells in tumor microenvironment.- Effects of Chinese traditional herbs on dendritic cells.- Future perspectives