Organelles in Disease

This book sheds light on how dysregulated organelle functions contribute to the pathology and progression of human diseases. To offer a broad perspective, they discuss basic, translational, and clinical aspects across scales, from molecules to cells, tissues and organisms. Rather than providing a comprehensive introduction to the field, the authors focus on recent advances in organelle research, with each chapter inviting readers to consider today's key questions in the respective field.

This book reviews the endoplasmic reticulum, Golgi Appartus, Lysosomes and other membrane-enclosed organelles, demonstrating how their dysregulated function contributes to various pathologies. The chapters not only offer a platform for new perspectives but also stimulate further investigations.

Given the translational nature of this subject, this book is a valuable resource for physiologists and clinicians alike.

Chapter "Lipid Droplets in Cancer" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Connects basic cell biology with medical application opportunities Provides insights from both laboratory and clinical research Contributes to a progessive scientific discussion in molecular medicine

Contenu
Golgi pH and Ion Homeostasis in Health and Disease.- Stress Granules in Cancer.- Lipid Droplets in Cancer.- Patterns of Ciliation and Ciliary Signaling in Cancer.- Targeting Cancer Lysosomes with Good Old Cationic Amphiphilic Drugs.- Cancer-Related Increases and Decreases in Calcium Signaling at the Endoplasmic Reticulum-Mitochondria Interface (MAMs).- Endosomal Acid-Base Homeostasis in Neurodegenerative Diseases.- Endolysosomal Disorders Affecting the Proximal Tubule of the Kidney: New Mechanistic Insights and Therapeutics.- Endo-Lysosomal Cation Channels and Infectious Diseases.