Redox Regulation and Therapeutic Approaches in Cancer

This book aims to provide an association of the major redox-sensitive pathways and networks involved in cancer. The initial chapter of the book discusses basic information about oxidative stress, its generation, and regulation (redox regulation or redox homeostasis) via cell signaling in normal and cancer cells. The book also explores antioxidants and metabolic events in cancer cells compared to normal cells. It further covers the application of nanoparticles in redox regulation in cancer cells. The role of redox regulation in cancer therapy, its influence, and its involvement in programmed cell death (PCD), metastasis, immune system, p53, and cell cycle/DNA damage repair pathways have been discussed in separate chapters. It further reviews the importance of dietary phytochemicals in redox regulation in normal and cancer pathophysiology. Towards the end, the book focuses on the role of redox balance, especially in ROS-dependent cellular processes in cancer stem cells.

Explores ROS and redox regulation in cancer stem cells and metabolism

Reviews the reactive oxygen species (ROS) and redox regulation in the pathophysiology of cancer

Discusses ROS and redox regulation and anticancer activity of natural dietary compounds

Auteur

Dr Mohinder Pal Bansal did MSc (Honours) in Biophysics in 1972 and PhD in 1980 on carcinogenesis from Department of Biophysics, Panjab University, Chandigarh (India). He worked as a faculty member since 1978 in the above department and superannuated in 2008 as professor. Main subject taught were Mammalian Physiology, Basic Molecular Biology, and Gene & Protein Engineering. After superannuation, he worked as emeritus fellow/scientist sponsored by UGC and ICMR for five years. During sabbaticals he has also worked as Research Associate and Visiting Faculty at the prestigious institution Department of Cell Biology, Baylor College of Medicine, Houston, Texas, USA. During this period, he has worked on the isolation and characterization of selenoproteins (having anticancer activity) and published work in reputed scientific journals. His core area of the research involved molecular pathophysiology under the influence of experimental oxidative stress and its modulation in spermatogenesis, atherosclerosis and carcinogenesis. Regulation of gene expression related to the endogenous antioxidative enzymes, transcription factors and their upstream activators (MAP kinases) were studied at transcriptional and translational level using RT-PCR and immunohistochemistry/ELISA etc.

He was listed as reviewer for the following research journals: Reproductive Toxicology, Molecular and Cellular Biochemistry, Free Radical Research, Atherosclerosis, Indian J Experimental Biology, Indian J Biochemistry and Biophysics. Out of his total 114 research publications, many are in the peer-reviewed national and international journals. He has authored two books, one as single author and another shared.

Contenu
Chapter 1_ ROS, redox regulation and signaling in cancer cells . -Chapter 2_ ROS and redox regulation/signaling in cancer stem cells and metabolism . - Chapter 3_ ROS/Redox regulation with dietary phytochemicals and role in anticancer activity . -Chapter 4_ ROS/Redox signaling and apoptosis/necrptosis/autophagy in cancer . - Chapter 5_ Cancer Metastasis, ROS/redox signaling and PCD resistance/redox metabolism . - Chapter 6_ Immune system, redox signaling and cancer immunity . - Chapter 7_ P53, ROS- redox regulation signaling, metabolic reprogramming and autophagy in cancer . - Chapter 8_ Cell cycle, DNA damage-repair systems and impact of redox regulation in cancer . - Chapter 9_ ROS, redox regulation and anticancer therapy . - Chapter 10_ Perspectives in ROS/redox regulation cancer therapy.