Magnetic Resonance Imaging

Leading experts in the use of MRI explain its basic principles and demonstrate its power to understand biological processes with numerous cutting-edge applications. To illustrate its capability to reveal exquisite anatomical detail, the authors discuss MRI applications to developmental biology, mouse phenotyping, and fiber architecture. MRI can also provide information about organ and tissue function based on endogenous cantrast mechanisms. Examples of brain, kidney, and cardiac function are included, as well as applications to neuro and tumor pathophysiology. In addition, the volume demonstrates the use of exogenous contrast material in functional assessment of the lung, noninvasive evaluation of tissue pH, the imaging of metabolic activity or gene expression that occur on a molecular level, and cellular labeling using superparamagnetic iron oxide contrast agents.

Includes supplementary material: sn.pub/extras

Texte du rabat

Even as magnetic resonance imaging (MRI) has matured into an invaluable diagnostic tool, it has also become a key experimental tool in biological research, where it demonstrates special sensitivity to a plethora of physiological factors, as well as a capacity for use all the way from cellular suspensions to in vivo human studies. In Magnetic Resonance Imaging: Methods and Biologic Applications, leading experts in the use of MRI from both academia and industry explain its basic principles and demonstrate its power to understand biological processes with numerous cutting-edge applications. To illustrate its capability to reveal exquisite anatomical detail, the authors discuss MRI applications to developmental biology, mouse phenotyping, and fiber architecture. MRI can also provide information about organ and tissue function based on endogenous contrast mechanisms. Examples of brain, kidney, and cardiac function are included, as well as applications to neuro- and tumor pathophysiology. In addition, the volume demonstrates the use of exogenous contrast material in functional assessment of the lung, noninvasive evaluation of tissue pH, the imaging of metabolic activity or gene expression that occur on a molecular level, and cellular labeling using superparamagnetic iron oxide contrast agents.
Cutting-edge and user-friendly, Magnetic Resonance Imaging: Methods and Biologic Applications illuminates for biological scientists the basic principles of MRI and shows how it can be used successfully to solve important biological problems.

Contenu
to Magnetic Resonance Imaging and Spectroscopy.- Magnetic Resonance Microscopy.- Anatomy.- Magnetic Resonance Imaging of Embryonic and Fetal Development in Model Systems.- Mouse Morphological Phenotyping With Magnetic Resonance Imaging.- Magnetic Resonance Microscopy of Mouse Brain Development.- Physiology.- Quantitative Perfusion Imaging Using Arterial Spin Labeling.- Physiology of Functional Magnetic Resonance Imaging.- Functional Magnetic Resonance Imaging of the Kidney.- Cardiac Magnetic Resonance Spectroscopy.- Pathophysiology.- Application of Magnetic Resonance Imaging to Study Pathophysiology in Brain Disease Models.- Magnetic Resonance Imaging of Tumor Physiology.- MRI in Preclinical Drug Development.- Novel Contrast Agents and Mechanisms.- Hyperpolarized Gas and Oxygen-Enhanced Magnetic Resonance Imaging.- Tissue pH Measurement by Magnetic Resonance Spectroscopy and Imaging.- Biological Applications of Manganese-Enhanced Magnetic Resonance Imaging.- Targeted Magnetic Resonance Imaging Contrast Agents.- Design and Characterization of Magnetic Resonance Imaging Gene Reporters.- Intracellular Endosomal Magnetic Labeling of Cells.