Life-Span Extension

In recent years, remarkable discoveries have been made concerning the underlying mechanisms of aging. This multidisciplinary book brings together a range of illuminating perspectives from researchers investigating the aging process in a variety of species.

Multidisciplinary, with viewpoints of experts studying the aging process in species ranging from yeast to man Discusses identification of common pathways that modulate longevity Provides overview of recent, remarkable discoveries about underlying mechanisms important to aging Explore studies in humans that have identified potentially important markers for successful aging Discusses single mutations that extend life span and have been identified in yeast, worms, flies, and mice Outlines emerging technologies and wide variety of systems that are now used to study aging

Contenu
Yeast.- Reprogramming Cell Survival and Longevity: The Role of Tor, Sch9, Ras, and Sir2.- Caenorhabditis elegans.- 2 Common Aging Mechanisms: Energy Metabolism and Longevity in Caenorhabditis elegans.- 3 Conserved Mechanisms of Life-Span Regulation and Extension in Caenorhabditis elegans.- Drosophila melanogaster.- The Genetic Architecture of Longevity.- Mild Stress and Life Extension in Drosophila melanogaster.- Rodents.- Global Food Restriction.- Growth Hormone and Aging in Mice.- Comparative Biology of Aging.- Exploiting Natural Variation in Life Span to Evaluate Mechanisms of Aging.- Slow Aging: Insights from an Exceptionally Long-Lived Rodent, the Naked Mole-Rat.- Life Extension in the Short-Lived Fish Nothobranchius furzeri.- Aging in Humans.- Aging and Longevity in Animal Models and Humans.