Total Synthesis of (±)-Maoecrystal V

In this thesis, the author describes the total synthesis of natural product Maoecrystal V in detail. In the first part of the thesis, the author introduces the research background and reviews the research progress in total synthesis of Maoecrystal V. In the second part, the author develops a novel and concise approach for the stereo selective construction of the tetracyclic model system of Maoecrystal V. The model system is accomplished in 8 steps with 20% yield. In the third part, the author describes the first successful total synthesis of Maoecrystal V and investigates four strategies for constructing the key tetrahydrofuran oxa-bridge skeleton. The total synthesis starts from a known compound and is accomplished in 17 steps with 1.2% yield. The successful total synthesis of Maoecrystal V will contribute to the development of efficient synthetic strategies for natural products and other compounds with complex structures.

Nominated by Peking University as an outstanding PhD thesis Comprehensively introduces the model study of Maoecrystal V Describes the first successful total synthesis of Maoecrystal V in detail Includes supplementary material: sn.pub/extras

Contenu

Research Background for Natural Product Maoecrystal V and Its Family.- The Model Study of Natural Product Maoecrystal V.- The total synthesis study of Maoecrystal V.- Summary.