Analysis of Samples of Clinical and Alimentary Interest with Paper-based Devices

This book presents two main sets of paper-based analytical systems. The first set is a platform for the analysis of glucose, cholesterol and uric acid in biological samples, and the second set is a cutting-edge electronic tongue system for the analysis of beverages (mineral water, beer, wine). This thesis also provides an extensive review of 33 methods of enzyme immobilization on paper which have been evaluated to enhance the storage stability of the proposed system for biomarker detection. From a practical perspective, this thesis covers a diverse set of topics related to paper-based sensing, including colorimetric and electrochemical detection methods, different sets of architecture (spot-tests, lateral and tangential flow assays), methods of fabrication (wax printing, cutting, impregnation with polymers), measurements in stationary and flow conditions as well computer modeling of proposed systems and sophisticated data analysis using chemometric techniques. This book is useful for PhD students working in this or a related field who require detailed information about methodology and background to this research.

Nominated as an outstanding Ph.D. thesis by the University of Campinas, Brazil Presents detailed, step-by-step procedures of fabrication of novel paper-based analytical devices Provides a strong theoretical background on paper-based technology, as well as a review of novel applications Describes stages of development of the first electrochemical paper-based electronic tongue system Includes supplementary material: sn.pub/extras

Auteur
Emilia Witkowska Nery studied Biotechnology, with specialization in Microbioanalytics and obtained her MSc. Eng. degree from Warsaw University of Technology (Poland) in 2010. In order to become a specialist in her field, she participated in a series of internships in different types of laboratories (genetics, organic chemistry, parasitology, biometrology) exploring major groups of living organisms. In 2015 she defended her Ph.D thesis developed at the Institute of Chemistry, UNICAMP (Brazil).Currently she is an Assistant Researcher at the Institute of Physical Chemistry, Polish Academy of Sciences, working on novel microfluidic systems, electrode arrays and disposable sensors. She was honoured with a prestigious FAPESP (Sao Paulo Research Foundation) scholarship.

Contenu
Introduction.- Literature Review.- Analysis of glucose, Cholesterol and uric acid.- Electronic tongue system for the analysis of beverages.- Conclusions.