The Quest for the Cure

Informationen zum Autor Brent R. Stockwell is an associate professor of biological sciences and chemistry at Columbia University and a Howard Hughes Medical Institute Early Career Scientist. He serves on the editorial board of Chemistry & Biology , has been awarded ten U.S. patents, and has published fifty-four scientific papers. Among his recent honors are a Burroughs Wellcome Fund Career Award at the Scientific Interface and a Beckman Young Investigator Award. Klappentext After more than 50 years of blockbuster drug development! skeptics fear we may be reaching the end of drug discovery to combat major diseases. A leading researcher in the exciting new science of chemical biology describes this dilemma and the powerful techniques that may bring drug research into the 21st century. Zusammenfassung After more than 50 years of blockbuster drug development! skeptics fear we may be reaching the end of drug discovery to combat major diseases. A leading researcher in the exciting new science of chemical biology describes this dilemma and the powerful techniques that may bring drug research into the 21st century. Inhaltsverzeichnis List of Illustrations Preface Acknowledgments Abbreviations Part I. The Vanishing Cures 1. The Drug Discovery Crisis 2. A New Science of Molecules 3. The Birth of the First Cancer Drugs 4. A New Company Creating Drug Combinations 5. The Undruggable RAS Protein 6. The Druggable Genome Part II. The Path to the Next Generation of Medicines 7. Peering Inside Proteins 8. The Nature of Interactions Between Proteins 9. From Protein-Protein Interactions to Personalized Medicines 10. A Revolution in Peptide Synthesis 11. A Vast Array of Drug Candidates 12. Moving Outside the Small Molecule Box 13. Accelerating the Arrival of Next-Generation Drugs Notes Glossary Index

Texte du rabat

After more than 50 years of blockbuster drug development, skeptics fear we may be reaching the end of drug discovery to combat major diseases. A leading researcher in the exciting new science of chemical biology describes this dilemma and the powerful techniques that may bring drug research into the 21st century.

Contenu

List of Illustrations
Preface
Acknowledgments
Abbreviations
Part I. The Vanishing Cures

1. The Drug Discovery Crisis
2. A New Science of Molecules
3. The Birth of the First Cancer Drugs
4. A New Company Creating Drug Combinations
5. The Undruggable RAS Protein
6. The Druggable Genome
   Part II. The Path to the Next Generation of Medicines
7. Peering Inside Proteins
8. The Nature of Interactions Between Proteins
9. From Protein-Protein Interactions to Personalized Medicines
10. A Revolution in Peptide Synthesis
11. A Vast Array of Drug Candidates
12. Moving Outside the Small Molecule Box
13. Accelerating the Arrival of Next-Generation Drugs
    Notes
    Glossary
    Index