Block Co-polymeric Nanocarriers: Design, Concept, and Therapeutic Applications

This book focuses on current advancements in the field of block copolymers and covers design, concept, and various therapeutic applications in the drug delivery. It also reviews the use of block copolymers in drug delivery applications from the development of sustained release products to smart polymeric delivery systems such as stimuli-responsive polymeric systems, for example, thermosensitive, redox-sensitive, photo-sensitive, and enzyme-sensitive. The book further discusses the nano assemblies from amphiphilic block copolymers as nanomedicine platforms for diagnosis and therapy due to their relatively small size, high drug loading capacity, controlled drug release, in vivo stability, and prolonged blood circulation. The chapters also review the various patents and ongoing clinical trials on the applications, covering several important new concepts and findings in the field of block copolymers. The book is aimed at researchers, academicians, and industrial scientists involved in the development of drug-delivery systems based on polymers.

Explains possible application of block copolymer in different aspects Elaborates on the role of block copolymers in cancer treatment Delves into the recent patent and clinical trial in the field of drug delivery aspects of block copolymers

Auteur

Dr. Neeraj Mishra is working as a professor and head in the Department of Pharmaceutics, Amity Institute of Pharmacy, Amity University Madhya Pradesh, Gwalior, Madhya Pradesh, India since July 2019. He has done his M. Pharm and Ph.D. in pharmaceutics from Dr. Harisingh Gour Central University, Sagar (M.P.). He has more than twenty years of teaching and research experience. He has published more than 100 research concept of novel drug delivery systems, localized drug delivery, targeted and controlled drug delivery of nanocarriers/ microparticles for the treatment of breast, and colon cancer, and neurodegenerative disorders. He has also written 6 books and 20 book chapters for national and international publishers along with 3 International and 3 National patents. Dr. Mishra also received the "Distinguished Professor Award" in 2019, from DST-SPAICS in the workshop held at Smriti College of Pharmaceutical Education and Research, M.P., India. Recently, Dr. Mishra received the "Distinguished Professor Award" 2021 from IPA, MP State Branch, Indore, India. Dr. Mishra has received "Best Academician Award" in the Indian Pharmacy Graduate Association, M.P. State International Conference held on 06th May 2023 at DAVV Auditorium, Indore, India. He is also received one MPCST Project entitled "Dual functional colon- targeted tofacitinib and probiotics loaded microparticles for the treatment of Inflammatory Bowel Disease".

Dr. Vikas Pandey is working as associate professor at Amity Institute of Pharmacy, Amity University Madhya Pradesh, Gwalior, India since July 2022. He has around 12 years of teaching and research experience. He has more than 30 publications on the concept of novel drug delivery systems, polymeric drug delivery, localized drug delivery, targeted and controlled drug delivery of nanocarriers, and microparticulate system for the treatment of various cancers like lung cancer, colon cancer, brain cancer, and neurodegenerative disorders. He has also written 17 books and has been granted 01 patent for his research.

Contenu

Ch 1 Introduction to block co-polymers.- Ch 2 Role of block co-polymers in drug delivery.- Ch 3 Role of block co-polymers in enhancement of poor solubility of drugs.- Ch 4 Synthesis and Selfassembly of block copolymers.- Ch 5 Role of block co-polymers in treatment of brain disorders.- Ch 6 Role of block co-polymers in treatment of neurodegenerative disorders.- Ch 7 Role of block co-polymers in colon cancer.- Ch 8 Role of block co-polymers in lung cancer.- Ch 9 Role of block co-polymers in IBD.- Ch 10 Role of block co-polymers in vaccine.- Ch 11 Role of block co-polymers in treatment of GIT disorders.- Ch 12 Role of block co-polymers in topical drug delivery.- Ch 13 Role of block co-polymers in targeted drug delivery.- Ch 14 Role of block co-polymers in ocular drug delivery.- Ch 15 Role of block co-polymeric micelles in drug delivery.- Ch 16 Applications of block co-polymers as Stimuli Responsive Copolymers.- Ch 17 Patented block co-polymers for various Therapeutics Applications.