Bipolar Depression: Molecular Neurobiology, Clinical Diagnosis, and Pharmacotherapy

This book brings together mental health professionals and researchers to offer the most up-to-date information on the diagnosis, treatment, and research surrounding bipolar depression. Its individual chapters provide valuable diagnostic information, allowing clinicians to distinguish between the various mood disorders. Further, they: review the course, outcome, and genetics of this highly heritable condition; offer a thorough overview of the neurobiology of the disorder, including what is known from neuroimaging work; delineate the treatment of bipolar depression in special populations such as children and pregnant women; address suicide, focusing on the need for assessment during both acute and maintenance treatment with interventions appropriate to a patient's symptoms and history; and cover acute and long-term treatment strategies for bipolar depression, including both traditional and novel therapeutics for the disorder, as well as non-pharmacological treatments.

This second edition reflects significant advances, including an improved understanding of the altered neurobiology of patients suffering from bipolar depression, new information on pathophysiology and genetic findings drawn from diverse studies, and a discussion of the significant strides made towards improved treatment with already available and novel agents.

Offers up-to-date information on the diagnosis, treatment, and research surrounding bipolar depression Explores basic neurobiological research as well as clinical applications Expands on the first edition with new studies on drug treatment Primarily aimed at researchers, clinicians, postgraduate students and trainees

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Section A: Bipolar Depression: Clinical Phenotype & Course of Illness.- 1) History of Bipolar Disorder and its Treatment.- 2) Clinical Diagnosis of Bipolar Depression (including differential diagnosis of UP and BP depression).- 3) Course and Outcome of Bipolar Disorder (focusing on depressive aspects).- 4) Suicide and Bipolar Disorder.- Section B: Bipolar Depression: Neurobiology.- 5) Genetics of Bipolar Disorder.- 6) Molecular and Cellular Neurobiology of Bipolar Depression.- 7) Non-Pharmacological Treatments and Chronobiological Aspects of Bipolar Depression: Implications for Novel Therapeutics.- 8) Neuroimaging of Bipolar Depression: Therapeutic Implications.- Section C: Acute and Long-term Treatment of Bipolar Depression.- 9) Pharmacological Treatment of the Acute and Continuation Phases of Bipolar Depression.- 10) Pharmacological Treatment of the Maintenance Phase of Bipolar Depression.- 11) Non-pharmacotherapeutic Somatic Treatments for Bipolar Depression (ECT, DBS, rTMS).- 12) Potential Novel Therapeutics for Bipolar Depression .- Section D: Treatment of Bipolar Disorder in Special Populations.- 13) Late Onset Bipolar Disorder.- 14) Childhood Onset Bipolar Disorder.- 15) The use of Psychotropic Medications in Bipolar Disorder during Pregnancy.- 16) Concluding Remarks.