Antimalarial Chemotherapy

Philip Rosenthal, MD, and a panel of leading malaria experts drawn from academia, the military, and international health organizations survey the latest scientific understanding of antimalarial chemotherapy, emphasizing the molecular mechanisms of resistance and the description of important new targets. Their survey covers the current status of malarial and antimalarial chemotherapy, the relevant biology and biochemistry of malaria parasites, the antimalarial drugs currently available, new chemical approaches to chemotherapy, and possible new targets for chemotherapy. Comprehensive and cutting-edge, Antimalarial Chemotherapy: Mechanisms of Action, Resistance, and New Directions in Drug Discovery clearly delineates all the basic and clinical research now addressing one of the world's major unresolved disease problems, work that is now powerfully driving the rapid pace of antimalarial drug discovery today.

Includes supplementary material: sn.pub/extras

Texte du rabat
At a time when the control of malaria is increasingly limited by the growing resistance of malaria parasites to available drugs, the need for a much better use of the existing drugs, as well as for the development of new antimalarials, has become urgent. In Antimalarial Chemotherapy: Mechanisms of Action, Resistance, and New Directions in Drug Discovery, a panel of leading malaria experts drawn from academia, the military, and international health organizations survey the latest scientific understanding of antimalarial chemotherapy, emphasizing the molecular mechanisms of resistance and the description of important new targets. The survey covers the current status of malarial and antimalarial chemotherapy, the relevant biology and biochemistry of malaria parasites, the antimalarial drugs currently available, and new chemical approaches to and possible new targets for chemotherapy. It also discusses, as essential background, the history of chemotherapy, the practical aspects of therapy, and the public health consequences of current problems in antimalarial chemotherapy.
Comprehensive and cutting-edge, Antimalarial Chemotherapy: Mechanisms of Action, Resistance, and New Directions in Drug Discovery clearly delineates all the basic and clinical research now addressing one of the world's major unresolved disease problems, work that is now powerfully driving the rapid pace of antimalarial drug discovery today.

Contenu
I Introduction.- 1 The Need for New Approaches to Antimalarial Chemotherapy.- 2 The History of Antimalarial Drugs.- 3 Transport and Trafficking in Plasmodium-Infected Red Cells.- 4 The Plasmodium Food Vacuole.- 5 Clinical and Public Health Implications of Antimalarial Drug Resistance.- II Established Antimalarial Drugs and Compounds Under Clinical Development.- 6 Chloroquine and Other Quinoline Antimalarials.- 7 8-Aminoquinolines.- 8 Mechanisms of Quinoline Resistance.- 9 Folate Antagonists and Mechanisms of Resistance.- 10 Artemisinin and Its Derivatives.- 11 AtovaquoneProguanil Combination.- 12 The Antimalarial Drug Portfolio and Research Pipeline.- III New Compounds, New Approaches, and New Targets.- 13 Novel Quinoline Antimalarials.- 14 New Antimalarial Trioxanes and Endoperoxides.- 15 Antibiotics and the Plasmodial Plastid Organelle.- 16 Fresh Paradigms for Curative Antimetabolites.- 17 Iron Chelators.- 18 Protease Inhibitors.- 19 Inhibitors of Phospholipid Metabolism.- 20 Development of New Malaria Chemotherapy by Utilization of Parasite-Induced Transport.