Poly(ADP-Ribosyl)ation

Poly(ADP-Ribosyl)ation comprises 19 chapters written by leading international experts in the field and is richly illustrated. Extensive bibliography is given in each chapter.

Poly(ADP-Ribosyl)ation, edited by Alexander Bürkle, provides the most comprehensive and up-to-date reference on this posttranslational modification of proteins, which is intimately linked with DNA repair, maintenance of genomic stability, transcriptional regulation, cell death and a variety of other cellular phenomena as well as with a variety of pathophysiological conditions, including ischemia-reperfusion damage (stroke, myocardial infarction), Parkinson's disease, Type I diabetes mellitus, hemorrhagic and septic shock and other inflammatory conditions. This book comprises 19 chapters written by leading international experts in the field and is richly illustrated.

Contenu
Enzymes in Poly(ADP-Ribose) Metabolism.- PARP-2: Structure-Function Relationship.- Targeting the Poly (ADP-Ribose) Glycohydrolase (PARG) Gene in Mammals.- DNA Damage Signaling through Poly(ADP-Ribose).- Roles of Poly(ADP-Ribose) Metabolism in the Regulation of Centrosome Duplication and in the Maintenance of Neuronal Integrity.- Functional Interactions of PARP-1 with p53.- Dynamic Interaction between PARP-1, PCNA and p21waf1/cip1.- PARP-1 as Novel Coactivator of NF-?B in Inflammatory Disorders.- PARP and Epigenetic Regulation.- PARP and the Release of Apoptosis-Inducing Factor from Mitochondria.- Genome Degradation by DNAS1L3 Endonuclease.- NAD: Metabolism and Regulatory Functions.- PARP-1 and the Shape of Cell Death.- Poly(ADP-Ribose) Polymerase (PARP) and Excitotoxicity.- Poly(ADP-Ribose) Polymerase and Ischemia-Reperfusion Injury.- Role of Poly(ADP-Ribose) Polymerase Activation in the Pathogenesis of Inflammation and Circulatory Shock.- Role of Poly-ADP-Ribosylation in Cancer Development.- PARP Inhibitors and Cancer Therapy.- Poly(ADP-Ribosyl)ation and Aging.